کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9114872 1156764 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal prorenin processing in growth hormone deficiency
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Abnormal prorenin processing in growth hormone deficiency
چکیده انگلیسی
Growth hormone deficiency (GHD) is associated with increased premature cardiovascular (CV) mortality. Abnormal cardiac structure and function, including autonomic adrenergic dysfunction as detected by heart rate variability analysis, have been described in GHD. Abnormal prorenin processing resulting in a reduced renin/prorenin ratio has been correlated with cardiac autonomic dysfunction, an established risk factor for CV mortality, in diabetic patients. We investigated renin/prorenin ratios in untreated GHD patients (n = 31) and in a group of GHD patients treated with GH (n = 23) and compared both groups to a group of 59 normal control subjects. The treated GHD group was replaced with GH for a mean duration of 49.4 ± 6.7 months. The mean renin/prorenin ratios were 0.0765 ± 0.0089 in the untreated GHD group, 0.113 ± 0.018 in the treated GHD group, and 0.304 ± 0.029 in the control group (P < 0.01, untreated GHD or treated GHD vs. normal controls; P = NS, untreated GHD vs. treated GHD). These results demonstrate that GHD is characterized by abnormal prorenin processing implicating concomitant cardiac autonomic adrenergic dysfunction, a risk factor for increased CV mortality. GH treatment resulted in a non-significant trend towards normalizing this defect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Growth Hormone & IGF Research - Volume 15, Issue 4, August 2005, Pages 251-255
نویسندگان
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