کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9118678 | 1157770 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
C-terminal part of AgRP stimulates insulin secretion through calcium release in pancreatic β Rin5mf cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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![عکس صفحه اول مقاله: C-terminal part of AgRP stimulates insulin secretion through calcium release in pancreatic β Rin5mf cells C-terminal part of AgRP stimulates insulin secretion through calcium release in pancreatic β Rin5mf cells](/preview/png/9118678.png)
چکیده انگلیسی
Agouti-related protein (AgRP) is an orexigenic peptide which is composed of three parts; the amino (N)-terminus, the middle part, and the carboxyl (C)-terminus. AgRP has been implicated in various cell signaling, but the precise role of each parts are currently unclear. In this study, we have attempted to determine which part of AgRP was critical for insulin secretion. We have found that the C-terminus of AgRP specifically increases the intracellular calcium concentration in pancreatic β Rin5mf cells in a PLC-dependent manner, whereas the middle part and C-terminus have little effects on calcium release. This calcium response can be observed in the freshly isolated primary β cells also. Moreover, amperometric measurement reveals that the C-terminus of AgRP increases the rate of exocytosis in Rin5mf cells. We further show that this region of AgRP is responsible for insulin secretion in a PLC-dependent manner. Taken together, these results indicate that the C-terminus of AgRP can participate in the insulin secretion in pancreatic β cells, through the modulation of calcium release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 39, Issue 4, August 2005, Pages 385-393
Journal: Neuropeptides - Volume 39, Issue 4, August 2005, Pages 385-393
نویسندگان
Hyeon Soo Kim, Sanatombi Yumkham, Hye-Young Lee, Jung-Hwa Cho, Mean-Hwan Kim, Duk-Su Koh, Sung Ho Ryu, Pann-Ghill Suh,