کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9118792 1157779 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of galanin and galanin(1-15) on central cardiovascular control
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Role of galanin and galanin(1-15) on central cardiovascular control
چکیده انگلیسی
Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses induced by Galanin(1-15) but not those elicited by Galanin; (B) both Galanin and Galanin(1-15) induce the expression of c-Fos in cardiovascular nuclei of the medulla oblongata with different temporal and spatial profiles; (C) the cardiovascular action of Galanin(1-15), but not Galanin, is mediated by peripheral β-receptor stimulation; (D) and it is demonstrated an antagonistic Galanin/α2-adrenoceptors interaction as well as a differential modulation of central cardiovascular responses of Angiotensin II by Galanin or Galanin(1-15). All these data strengthen the involvement of both Galanin molecules as neuromodulators on central cardiovascular regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 39, Issue 3, June 2005, Pages 185-190
نویسندگان
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