کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9127197 | 1569974 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sp-family of transcription factors regulates human SHIP2 gene expression
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Sp-family of transcription factors regulates human SHIP2 gene expression Sp-family of transcription factors regulates human SHIP2 gene expression](/preview/png/9127197.png)
چکیده انگلیسی
We have characterized the regulation of human SH-2 containing inositol 5â²-phosphatase 2 (SHIP2) gene expression. First, the transcription initiation sites and the sequence of the 5â² upstream region of human SHIP2 gene were elucidated. Next, the minimal promoter of the human SHIP2 gene was identified by reporter gene assays in HL60 cells and differentiated human subcutaneous white adipocytes. An Sp1 element proximal to the transcription initiation site was indispensable for full promoter activity and bound specifically by Sp1 and Sp3 proteins. These findings suggest that human SHIP2 gene expression, like other housekeeping genes, is controlled by the Sp-family of transcription factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 348, 28 March 2005, Pages 135-141
Journal: Gene - Volume 348, 28 March 2005, Pages 135-141
نویسندگان
Satoru Ishida, Akihiro Funakoshi, Kyoko Miyasaka, Haruo Iguchi, Soichi Takiguchi,