کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9152297 1167444 2005 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Airway mechanosensors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Airway mechanosensors
چکیده انگلیسی
A mechanosensory unit is a functional unit that contains multiple receptors (or encoders) with different characteristics, including rapidly adapting receptors, slowly adapting receptors, and deflation-activated-receptors. Each is capable of sensing different aspects of lung mechanics. The sensory unit is both a transducer and a processor. Significant information integration occurs at the intra-encoder and inter-encoder levels. Within an encoder, the information is encoded as analog signals and integrated by amplitude modulation. Information from each single stretch-activated channel is processed through several levels of temporal and spatial summation, producing a generator potential that encodes averaged overall information within the encoder. This analog signal is transformed into a digital signal in the form of action potentials that are encoded as frequency (frequency modulation). These all-or-none propagated action potentials from different encoders interact through a competitive selection mechanism. Such inter-encoder interaction may occur at several levels, because of the fractal nature of the sensory unit. Inter-encoder interaction retains representative information but eliminates redundant information, resulting in the final output to the central nervous system, where multiple decoders specific for different variables decipher the encoded information for further processing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 148, Issue 3, 12 October 2005, Pages 217-243
نویسندگان
,