کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9152343 | 1571358 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effect of sleep-wake states on lingual and dorsal neck muscle activity in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential effect of sleep-wake states on lingual and dorsal neck muscle activity in rats Differential effect of sleep-wake states on lingual and dorsal neck muscle activity in rats](/preview/png/9152343.png)
چکیده انگلیسی
Postural tone is reduced during slow-wave sleep (SWS) and absent during rapid eye movement sleep (REMS). In obstructive sleep apnea subjects, upper airway dilating muscles, including those of the tongue, show a similar pattern; this contributes to sleep-related airway obstructions. However, in healthy subjects, state-dependent changes in the activity of pharyngeal muscles are variable. In seven chronically instrumented Sprague-Dawley rats, an animal model used to study sleep and sleep-disordered breathing, we quantified lingual and postural muscle activity across the sleep-wake states by measuring the root mean square levels of the electromyograms (EMG) in successive 10 s intervals collected during 2 h of recording at a constant circadian time (1-3 p.m.). The nuchal EMG was low and steady during SWS and further reduced with occasional twitches during REMS. In contrast, the mean lingual EMG during SWS was only 5.9 ± 1.6% (S.E.) of its mean in wakefulness, and during REMS, it increased to 46 ± 15% (S.E.) (p < 0.03) due to the appearance of phasic bursts, the intensity of which progressively increased. The lingual and nuchal activities also had different time courses during state transitions. In obstructive sleep apnea subjects, the sleep-wake changes in the activity of pharyngeal muscles may become similar to those in postural muscles as a result of pharyngeal tone adaptations to the disorder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 147, Issues 2â3, 28 July 2005, Pages 191-203
Journal: Respiratory Physiology & Neurobiology - Volume 147, Issues 2â3, 28 July 2005, Pages 191-203
نویسندگان
Jackie W. Lu, Graziella L. Mann, Richard J. Ross, Adrian R. Morrison, Leszek Kubin,