کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
939467 1475398 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans
چکیده انگلیسی


• A double-blind, placebo-controlled crossover study of Exendin-[9-39] (Ex-9).
• We examine the satiating effects of GLP-1 in normal weight humans.
• Subjective appetite and objective food intake were similar between treatments.
• Glucose, insulin and GLP-1 were elevated during treatment with Ex-9.
• Antagonism of GLP-1 is not sufficient to suppress satiety or voluntary food intake.

Glucagon-like peptide 1 (GLP-1) has incretin effects that are well-documented, but the independent role of GLP-1 action in human satiety perception is debated. We hypothesized that blockade of GLP-1 receptors would suppress postprandial satiety and increase voluntary food intake. After an overnight fast, eight normal weight participants (seven men, BMI 19–24.7 kg/m2, age 19–29 year) were enrolled in a double-blind, placebo-controlled, randomized crossover study of the GLP-1 antagonist Exendin-[9-39] (Ex-9) to determine if the satiating effects of a meal are dependent on GLP-1 signaling in humans. Following a fasting blood draw, iv infusion of Ex-9 (600–750 pmol/kg/min) or saline began. Thirty minutes later, subjects consumed a standardized breakfast followed 90 min later (at the predicted time of maximal endogenous circulating GLP-1) by an ad libitum buffet meal to objectively measure satiety. Infusions ended once the buffet meal was complete. Visual analog scale ratings of hunger and fullness and serial assessments of plasma glucose, insulin, and GLP-1 concentrations were done throughout the experiment. Contrary to the hypothesis, during Ex-9 infusion subjects reported a greater decrease in hunger due to consumption of the breakfast (Ex-9 −62 ± 5; placebo −41 ± 9; P = 0.01) than during placebo. There were no differences in ad libitum caloric intake between Ex-9 and placebo. Ex-9 increased glucose, insulin, and endogenous GLP-1, which may have counteracted any effects of Ex-9 infusion to block satiety signaling. Blockade of GLP-1 receptors failed to suppress subjective satiety following a standardized meal or increase voluntary food intake in healthy, normal-weight subjects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Appetite - Volume 82, 1 November 2014, Pages 85–90
نویسندگان
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