Acute effect of soybean beta-conglycinin hydrolysate ingestion on appetite sensations in healthy humans

A hydrolysate prepared from soybean beta-conglycinin reduced food intake through cholecystokinin release in rats; however, effects of the hydrolysate on human appetites are unknown. In this study, healthy volunteers ingested 3 g of the beta-conglycinin hydrolysate (BconB) and/or a soy protein hydrolysate (HN) contained in a beverage or in a jelly. Appetite profiles (hunger, fullness and prospective consumption) after the ingestion and palatability of test jellies were recorded. Fullness was rated higher, and hunger was rated lower after BconB ingestion as compared to HN ingestion. These results demonstrate that 3 g of BconB is effective to enhance fullness and reduce hunger sensations in healthy humans.

► Effect of soybean ß-conglycinin peptide (BconB) on human appetite was investigated.
► Compared to a soy protein hydrolysate, BconB ingestion enhanced fullness sensation.
► Single ingestion of BconB is effective to induce satiety in healthy humans.