کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9478218 | 1324780 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of mammalian and fish cell line cytotoxicity: impact of endpoint and exposure duration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of mammalian and fish cell line cytotoxicity: impact of endpoint and exposure duration Comparison of mammalian and fish cell line cytotoxicity: impact of endpoint and exposure duration](/preview/png/9478218.png)
چکیده انگلیسی
The comparison of cytotoxic potencies shows that, in general, the fish cell lines and the mammalian cell line are almost equally sensitive towards the cytotoxic action of chemicals. The mammalian cell line assay, however, becomes considerably more sensitive, by factors of 3.4-8.5, than the fish cell line assays, if cell growth instead of cell survival is used as endpoint. It is concluded, that cell proliferation might be a better endpoint than cell survival and that mammalian cell lines might be suited to assess fish acute toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 71, Issue 3, 10 February 2005, Pages 229-236
Journal: Aquatic Toxicology - Volume 71, Issue 3, 10 February 2005, Pages 229-236
نویسندگان
Michael Gülden, Sabine Mörchel, Hasso Seibert,