کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9645103 1433682 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
apoE isoforms and measures of anxiety in probable AD patients and Apoe−/− mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
apoE isoforms and measures of anxiety in probable AD patients and Apoe−/− mice
چکیده انگلیسی
Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe−/− male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe−/− mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with ɛ4/ɛ4 showed higher anxiety scores than those with ɛ3/ɛ3. We conclude that human apoE isoforms have differential effects on measures of anxiety.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 26, Issue 5, May 2005, Pages 637-643
نویسندگان
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