کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9645103 | 1433682 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
apoE isoforms and measures of anxiety in probable AD patients and Apoeâ/â mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoeâ/â male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoeâ/â mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with É4/É4 showed higher anxiety scores than those with É3/É3. We conclude that human apoE isoforms have differential effects on measures of anxiety.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 26, Issue 5, May 2005, Pages 637-643
Journal: Neurobiology of Aging - Volume 26, Issue 5, May 2005, Pages 637-643
نویسندگان
Jennifer Robertson, Justine Curley, Jeffrey Kaye, Joseph Quinn, Timothy Pfankuch, Jacob Raber,