A convenient three-component reaction for the construction of multifunctional 6-fluoroalkyl-1,2,3,4-tetrahydropyrimidines

β-Fluoroalkylenaminoketones were prepared and their reaction with primary amines and formaldehyde were studied. Multifunctional 6-fluoroalkyl-1,2,3,4-tetrahydropyrimidines were synthesized conveniently from the three-component reaction in good yields under mild conditions.