Synthesis and bioactivity of fluorine compounds containing isoxazolylamino and phosphonate groups

A series of (2, or 4)-fluorophenyl-α-aminophosphonate containing isoxazole moiety were synthesized by the reaction of fluorobenzoaldehyde, 3-amino-5-methylisoxazole and dialkyl phosphite under unltrasound irradiation without solvent and catalyst. The bioassay tests showed that these title compounds exhibit moderate anticancer activity in vitro by MTT method. The structure of 4c was determined by X-ray single crystal structure analysis.