کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9769153 1501241 2005 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil
چکیده انگلیسی
Sixty-four new indanones and thiaindanones related to donepezil were synthesized and evaluated in vitro as potential AChE inhibitors. Among them, 11 derivatives were found to inhibit the enzyme in the submicromolar range; the best compound revealed its inhibitory activity with an IC50 in the same range (0.06 μM) than the reference compound, donepezil (IC50 = 0.02 μM).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 12, December 2005, Pages 1222-1245
نویسندگان
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