کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9769161 1501241 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide
چکیده انگلیسی
In this paper, the binding mode of original pyridinic compounds structurally related to nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, is analyzed by docking simulations in order to understand structure-activity relationships of this family. Structural modifications are proposed to reverse the selectivity of the more active inhibitor of the series characterized by a preferential activity on COX-1. On the basis of these modifications, a new compound with a bromo substituent was designed and showed a COX-2 selective inhibition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 12, December 2005, Pages 1316-1324
نویسندگان
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