کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769277 | 1501248 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins](/preview/png/9769277.png)
چکیده انگلیسی
As an effort to develop novel selective hypoxia-cytotoxins and to improve bioavailability and pharmacological and toxicological properties of quinoxaline N1,N4-dioxide derivatives (L1 = 3-amino-6(7)-chloroquinoxaline-2-carbonitrile N1,N4-dioxide, L2 = 3-amino-6(7)-bromoquinoxaline-2-carbonitrile N1,N4-dioxide and L3 = 3-amino-6(7)-methylquinoxaline-2-carbonitrile N1,N4-dioxide) and to get a synergism among metals and these type of bioreductive agents, L2 and three novel Cu(II) complexes of general formulae [CuII(H2O)x(L - H)2], where L = L1 (x = 1), L2 (x = 0) or L3 (x = 2) were developed. L2 and complexes were synthesized and structurally characterized by elemental and thermal analyses, and FTIR, electronic, MS, NMR, and EPR spectroscopies. The new compounds were subjected to cytotoxic evaluation in V79 cells in hypoxic and aerobic conditions. The complexes showed excellent selective cytotoxicity in hypoxia, being their cytotoxicity similar to or higher than that of the ligands L1-L3. Besides, the copper complexes were so poorly cytotoxic in oxia as the free ligands. In addition, for the first time Cu(II)-quinoxaline complexes are reported as a family of hypoxic cytotoxins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 5, May 2005, Pages 473-480
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 5, May 2005, Pages 473-480
نویسندگان
MarÃa H. Torre, Dinorah Gambino, Jeannette Araujo, Hugo Cerecetto, Mercedes González, MarÃa Laura Lavaggi, Amaya Azqueta, Adela López de Cerain, Antonio Monge Vega, Ulrich Abram, Antonio J. Costa-Filho,