کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769292 | 1501249 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity](/preview/png/9769292.png)
چکیده انگلیسی
The six novel 4-methylcoumarins bearing different functionalities such as amino, hydroxy, N-acetyl, acetoxy and nitro have been synthesized and confirmed on the basis of their spectral data (1H-, 13C-NMR, UV, IR and EI mass). They were examined for the first time for their effect on NADPH dependent liver microsomal lipid peroxidation in vitro, and the results were compared with other model 4-methylcoumarin derivatives to establish the structure-activity relationship. Our studies demonstrated that amino group is an effective substitute for the hydroxyl group for antioxidant property and produced a dramatic inhibition of lipid peroxidation. Ortho dihydroxy and ortho hydroxy-amino coumarins were found to possess highest antioxidant and radical scavenging activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 4, April 2005, Pages 413-420
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 4, April 2005, Pages 413-420
نویسندگان
Yogesh K. Tyagi, Ajit Kumar, Hanumantharao G. Raj, Parag Vohra, Garima Gupta, Ranju Kumari, Pankaj Kumar, Rajinder K. Gupta,