کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769319 | 1501252 | 2005 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study](/preview/png/9769319.png)
چکیده انگلیسی
New platelet glycoprotein IIb/IIIa (GP IIb/IIIa, integrin αIIbβ3) antagonists were prepared on a 2H-1,4-benzoxazine-3(4H)-one scaffold. Their anti-aggregatory activities in human platelet rich plasma and their affinity towards αIIbβ3 and αVβ3 integrins were assessed. Various substitution positions and side chain variations were studied. In contrast to the generally accepted model, compounds containing ethyl esters as aspartate mimetics were in general more active than the corresponding free acids. We suggest an explanation for the observed behaviour of these new compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 1, January 2005, Pages 25-49
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 1, January 2005, Pages 25-49
نویسندگان
Marko Anderluh, Jožko Cesar, Petra Å tefaniÄ, Danijel Kikelj, Damjan JaneÅ¡, Jernej Murn, Kristina Nadrah, Mojca Tominc, Elisabeth Addicks, Athanassios Giannis, Mojca Stegnar, Marija Sollner Dolenc,