کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9878921 | 1534495 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An evaluation of efficacy and safety of reboxetine in elderly patients affected by “retarded” post-stroke depression
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An evaluation of efficacy and safety of reboxetine in elderly patients affected by “retarded” post-stroke depression An evaluation of efficacy and safety of reboxetine in elderly patients affected by “retarded” post-stroke depression](/preview/png/9878921.png)
چکیده انگلیسی
Depression occurs frequently in post-stroke patients and appears to be associated with an impairment in their rehabilitation and functional recovery. Although selective serotonin reuptake inhibitors (SSRI) are often used in post-stroke depression (PSD), it has been observed that only a subset of patients is responsive to this treatment. Other patients respond to tricyclic antidepressants or MAO inhibitors, which, however, may not have a favorable profile of safety and tolerability in post-stroke patients. In this double-blinded, placebo-controlled study, we evaluated the efficacy and tolerability of the noradrenaline reuptake inhibitor, reboxetine, in a subset of PSD patients classified as affected by “retarded” depression. Reboxetine (4 mg, twice daily, for 16 weeks) was administered to patients that developed depression after a single ischaemic or hemorrhagic stroke. We assessed the severity of depressive symptoms by the Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS). HDRS and BDI scores (mean ± S.D.) at baseline were, respectively, 24 ± 1.31 and 19.87 ± 1.46 in the placebo group, 24.06 ± 1.52 and 20.56 ± 2.16 in the reboxetine group. After 16 weeks, HDRS and BDI mean scores were respectively 22.73 ± 2.4 and 18.4 ± 3.33 in the placebo group, 9.26 ± 2.15 and 8.06 ± 3.43 in the reboxetine group [p < 0.01 versus the respective baseline (paired t-test); #p < 0.01 versus retarded depressed patients treated with placebo (one-way analysis of variance (ANOVA) applied to the difference from baseline, associated with Dunnett's t-test to isolate the differences)]. Reboxetine showed a good efficacy, safety and tolerability in PSD patients affected by “retarded” depression. We conclude that reboxetine is well tolerated and may be a useful therapeutic option in PSD patients with “retarded” depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 40, Issue 3, MayâJune 2005, Pages 275-285
Journal: Archives of Gerontology and Geriatrics - Volume 40, Issue 3, MayâJune 2005, Pages 275-285
نویسندگان
Liborio Rampello, Alessandro Alvano, Santina Chiechio, Rocco Raffaele, Ignazio Vecchio, Mariano Malaguarnera,