کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9880308 1535225 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overcoming inhibitors in myelin to promote axonal regeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Overcoming inhibitors in myelin to promote axonal regeneration
چکیده انگلیسی
Similar to other axon guidance molecules, MAG is bifunctional. When cultured on MAG-expressing cells, dorsal root ganglia neurons (DRG) older than post-natal day 4 (PND4) extend neurites 50% shorter on average than when cultured on control cells. In contrast, MAG promotes neurite outgrowth from DRG neurons from animals younger than PND4. The response switch, which is also seen in retinal ganglia (RGC) and Raphe nucleus neurons, is concomitant with a developmental decrease in the endogenous neuronal cAMP levels. We report that artificially increasing cAMP levels in older neurons can alter their growth-state and induce axonal growth in the presence of myelin-associated inhibitors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 233, Issues 1–2, 15 June 2005, Pages 43-47
نویسندگان
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