کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9904213 | 1546406 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Establishing a Platform for Immunotherapy: Clinical Outcome and Study of Immune Reconstitution after High-Dose Chemotherapy with Progenitor Cell Support in Breast Cancer Patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Tumor vaccine after high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) aims at directing immune recovery toward tumor responses after optimizing minimal residual disease. We have characterized T-cell recovery and tumor response after a regimen devised as a platform for such immunotherapy. One hundred patients with high-risk or metastatic breast cancer received 3 to 7 cycles of paclitaxel and cyclophosphamide (overall response rate, 78%) and then HDC with melphalan and etoposide. Seventy-one patients received HDC and ASCT (no mortality at 100 days). At 24 months after transplantation, progression-free and overall survival probabilities for patients with stage IIIA, IIIB, and IV disease were 82%, 81%, and 42% and 100%, 94%, and 68%, respectively. The median progression-free and overall survivals from entry on study for stage IV patients were 15.3 and 38.1 months, respectively. CD3+, CD8+, and CD4+ cells were severely depleted after ASCT. Although total CD8+ T-cell numbers approached the normal range by 3 months, most of these cells were CD28â. Naive CD45RA+CD4+ T cells approached the normal range only 18 months after ASCT and only in younger patients. The described observations provide the basis for devising a strategy for cancer vaccine administration after ASCT. Incorporating immune reconstitution enhancement after ASCT may be advantageous.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biology of Blood and Marrow Transplantation - Volume 11, Issue 6, June 2005, Pages 472-483
Journal: Biology of Blood and Marrow Transplantation - Volume 11, Issue 6, June 2005, Pages 472-483
نویسندگان
Claude Sportès, Nicole J. McCarthy, Frances Hakim, Seth M. Steinberg, David J. Liewehr, David Weng, Shivaani Kummar, Juan Gea-Banacloche, Catherine K. Chow, Robert M. Dean, Kathleen M. Castro, Donna Marchigiani, Michael R. Bishop, Daniel H. Fowler,