کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9904240 | 1546408 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced-intensity unrelated cord blood transplantation for patients with advanced malignant lymphoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
We report the results of reduced-intensity unrelated cord blood transplantation (RI-UCBT) in patients with advanced malignant lymphoma. Twenty patients (median age, 46.5 years; range, 27-66 years) underwent RI-UCBT with a preparative regimen consisting of fludarabine 125 mg/m2, melphalan 80 mg/m2, and 4 Gy of total body irradiation. The median infused total cell dose was 2.75 Ã 107/kg (range, 2.3-3.4 Ã 107/kg). Graft-versus-host disease (GVHD) prophylaxis was composed of cyclosporine or tacrolimus alone. Fifteen patients achieved primary neutrophil engraftment after a median of 20 days. Eight patients developed grade II to IV acute GVHD, and 2 developed chronic GVHD. Of the 16 patients with evaluable disease, 10 achieved a complete response. Primary disease recurred in 1 patient, and transplant-related mortality within 100 days occurred in 8 of 20 patients. The estimated 1-year probability of progression-free survival was 50%. These data suggest that RI-UCBT is a feasible option for patients with refractory lymphoma who lack an HLA-matched donor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biology of Blood and Marrow Transplantation - Volume 11, Issue 4, April 2005, Pages 314-318
Journal: Biology of Blood and Marrow Transplantation - Volume 11, Issue 4, April 2005, Pages 314-318
نویسندگان
Koichiro Yuji, Shigesaburo Miyakoshi, Daisuke Kato, Yuji Miura, Tomohiro Myojo, Naoko Murashige, Yukiko Kishi, Kazuhiro Kobayashi, Eiji Kusumi, Hiroto Narimatsu, Tamae Hamaki, Tomoko Matsumura, Masahiro Kami, Takahiro Fukuda, Shigeru Masuo,