کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9908980 | 1548427 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The impact of plasma folate levels of mothers and newborns on intrauterine growth retardation and birth weight
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کلمات کلیدی
ETsRDIIUGRenvironmental tobacco smoke - دود سیگار محیطیSmoking - سیگار کشیدنbody mass index - شاخص توده بدنBMI - شاخص توده بدنیintrauterine growth retardation - عقب ماندگی رشد داخل رحمیFolate - فولاتPolycyclic aromatic hydrocarbons - هیدروکربن آروماتیک چندحلقهایPAHs - هیدروکربن های آروماتیک چند حلقه ایBirth weight - وزن هنگام تولد
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Folate plays an important role in the genomic stability of human cells. In our studies of the impact of environmental pollution on human health, we have found that air pollution can affect pregnancy outcome. As it may be also affected by nutrition, we examined the effect of plasma folate levels of mothers and newborns on intrauterine growth retardation (IUGR) and birth weight (BW) in cohorts from Prague (NÂ =Â 319) and Teplice (NÂ =Â 444). The lower plasma levels (<6.1Â nmol/L) were observed in 7.1% of mothers in Prague, and in 9.6% of mothers in Teplice. The higher plasma levels (>36.5Â nmol/L) were observed in 28.4% of mothers in Prague, and in 15.7% of mothers in Teplice. The higher plasma levels were observed in 75.4% of newborns in Prague, and 73.2% of newborns in Teplice. When comparing maternal high versus low folate plasma levels and IUGR by logistic regression, the risk of IUGR was significantly decreased for European cohort (according to ethnicity) with gestation age >36 weeks [NÂ =Â 536, ORÂ =Â 0.44, PÂ =Â 0.026], and even more pronounced in the group of European smokers [NÂ =Â 157, ORÂ =Â 0.14, PÂ =Â 0.015]. Using multiple regression analysis, plasma folate levels of mothers and newborns significantly affected the birth weight of newborns of smoking mothers (PÂ <Â 0.05). The obtained results seem to indicate a positive effect of folate on pregnancy outcome, especially its potential to decrease the risk of IUGR in European population and lower birth weight in smoking European mothers. It would be warranted to study the effect of folate levels on pregnancy outcomes in the relationship to different environmental pollution and life styles of mothers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 591, Issues 1â2, 11 December 2005, Pages 302-310
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 591, Issues 1â2, 11 December 2005, Pages 302-310
نویسندگان
Radim J. Sram, Blanka Binkova, Zdena Lnenickova, Ivo Solansky, Jan Dejmek,