کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9909006 | 1548429 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis](/preview/png/9909006.png)
چکیده انگلیسی
We have measured the inhibition of the mutagenicity of the mycotoxin aflatoxin-B1 in the liver of the rat by plant material of Scutellaria baicalensis, or Huang-qin. The addition of one percent dried Huang-qin to the feed of the animals reduced the mutant frequency of a subsequent administration of aflatoxin-B1 by approximately 60 and 77%, respectively, for two different batches of the plant material. The addition of Huang-qin also increased the expression of the gene for glutathione S-transferase A5 subunit by 2.5-3.0-fold, and decreased expression of P450 cytochrome 3A2 by 1.8-2.0-fold. The greater increase of the expression of the GST gene may result in the protection shown by Huang-qin. The sensitivity of the hepatic mitochondria to swelling, a measure of the mitochondrial permeability transition, is increased significantly in animals that are on a diet containing Huang-qin. This may lead to increased sensitivity to apoptosis on treatment with toxic compounds. The two batches of Huang-qin material show differences in both chemical composition and preventive potential. This study demonstrates how a combination of generating and analysis of plant varieties together with a mammalian assay for efficacy may improve the search for better plant-based prevention of cancer initiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 578, Issues 1â2, 15 October 2005, Pages 15-22
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 578, Issues 1â2, 15 October 2005, Pages 15-22
نویسندگان
Johan G. de Boer, Brendan Quiney, Patrick B. Walter, Cynthia Thomas, Kimberley Hodgson, Susan J. Murch, Praveen K. Saxena,