کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9913317 1550308 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Employing the immunological synapse in AML: Development of leukemic dendritic cells for active specific immunization
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Employing the immunological synapse in AML: Development of leukemic dendritic cells for active specific immunization
چکیده انگلیسی
Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to naïve T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 210, Issues 2–4, 19 August 2005, Pages 249-257
نویسندگان
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