کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9954457 | 1547875 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic changes in HLA-DR expression during short-term and long-term ibrutinib treatment in patients with chronic lymphocytic leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
There is the first evidence of changes in the kinetics of B cell antigen receptor (BCR) internalisation of neoplastic cells in chronic lymphocytic leukemia (CLL) after the short-term and long-term administration of ibrutinib. We aimed to assess the influence of short-term and long-term ibrutinib treatment on the HLA-DR expression on CLL cells, T cells and monocytes. The immunophenotyping of CLL and immune cells in peripheral blood was performed on 16 high-risk CLL patients treated with ibrutinib. After early ibrutinib administration, the HLA-DR expression on CLL cells reduced (Pâ=â0.032), accompanied by an increase in CLL cell counts in peripheral blood (Pâ=â0.001). In vitro culturing of CLL cells with ibrutinib also revealed the reduction in the HLA-DR expression at protein and mRNA levels (Pâ<â0.01). The decrease in HLA-DR on CLL cells after the first month was followed by the gradual increase of its expression by the 12th month (Pâ=â0.001). A one-month follow-up resulted in elevated absolute counts of CD4+ (Pâ=â0.002) and CD8+ (Pâ<â0.001) T cells as well as CD4+ and CD8+ cells bearing HLA-DR (Pâ<â0.01). The long-term administration of ibrutinib was associated with the increased numbers of CD4+ bearing HLA-DR (Pâ=â0.006) and elevation of HLA-DR expression on all monocyte subsets (P ⤠0.004). Our results provide the first evidence of the time-dependent immunomodulatory effect of ibrutinib on CLL and T cells and monocytes. The clinical consequences of time-dependent changes in HLA-DR expression in ibrutinib treated patients deserve further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 72, September 2018, Pages 113-119
Journal: Leukemia Research - Volume 72, September 2018, Pages 113-119
نویسندگان
Gayane Manukyan, Peter Turcsanyi, Zuzana Mikulkova, Gabriela Gabcova, Renata Urbanova, Petr Gajdos, Veronika Smotkova Kraiczova, Sarka Zehnalova, Tomas Papajik, Eva Kriegova,