Keywords: 4-HNE، 4-hydroxy-2-nonenal; 4-HNE, 4-hydroxy-2-nonenal; ATF6, activating transcription factor 6; BiP, binding immunoglobulin protein; EIF2α, eukaryotic initiation factor 2 alpha; FAs, fatty acids; Fis1, fission 1; H&E, hematoxylin and eosin; HFD, high-fat diet; IRE1, inositol-requir
مقالات ISI 4-HNE، 4-hydroxy-2-nonenal (ترجمه نشده)
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Keywords: 4-HNE، 4-hydroxy-2-nonenal; 4-HNE, 4-hydroxy-2-nonenal; AC, alternating current; ANOVA, analysis of variance; ELF-EFs, extremely low-frequency electric fields; ERPs, event-related potentials; MMN, mismatch negativity; PBS, phosphate-buffered saline; SOD, synthesis of superoxide dism
Impacts of common variants in ALDH2 on coronary artery disease patients
Keywords: 4-HNE، 4-hydroxy-2-nonenal; GWAS, genome-wide association studies; ALDH2, aldehyde dehydrogenase 2; CAD, coronary artery disease; 4-HNE, 4-hydroxy-2-nonenal; MAF, minor allele frequency; HWE, Hardy Weinberg equilibriumALDH2; Common variant; Coronary artery disease; Outcome
Revealing mechanisms of selective, concentration-dependent potentials of 4-hydroxy-2-nonenal to induce apoptosis in cancer cells through inactivation of membrane-associated catalase
Keywords: 4-HNE، 4-hydroxy-2-nonenal; 3-AT, 3-aminotriazole; 4-HNE, 4-hydroxy-2-nonenal; AEBSF, 4-(2-aminoethyl)benzenesulfonyl fluoride; DUOX, dual oxidase; EUK-134, chloro[2,2′-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]] manganese; FBS, fetal bovine serum; FeTPPS
Genistein modulates oxidative stress in breast cancer cell lines according to ERα/ERβ ratio: Effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes
Keywords: 4-HNE، 4-hydroxy-2-nonenal; CAT, catalase; DCFDA, 2′,7′-dichlorofluorescein diacetate; ERα, estrogen receptor alpha; ERβ, estrogen receptor beta; GEN, genistein; 4-HNE, 4-hydroxy-2-nonenal; MnSOD, manganese superoxide dismutase; Δψm, mitochondrial membrane potential; NAO, Nonyl Acri
Mitochondrial dysfunction and the inflammatory response
Keywords: 4-HNE، 4-hydroxy-2-nonenal; 4-HNE, 4-hydroxy-2-nonenal; ∆ψm, mitochondrial membrane potential; AD, Alzheimer's disease; AP-1, activator protein-1; APC, antigen-presenting cell; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; ATP, adenosine triph
Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells
Keywords: 4-HNE، 4-hydroxy-2-nonenal; ALD, alcoholic liver disease; Erk, extracellular-signal-related kinase; JNK, c-Jun-N-terminal kinase; GSK3β, glycogen synthase kinase 3 beta; 4-HNE, 4-hydroxy-2-nonenal; MDM2, ubiquitin ligase murine double minute oncogene 2; NASH, nonalcoholic steatohepa
Inhibition of aldehyde dehydrogenase 2 activity enhances antimycin-induced rat cardiomyocytes apoptosis through activation of MAPK signaling pathway
Keywords: 4-HNE، 4-hydroxy-2-nonenal; Aldehyde dehydrogenase 2; Cardiomyocyte; ApoptosisALDH2, Aldehyde dehydrogenase 2; ERK1/2, extracellular signal-regulated kinase; JNK, c-Jun NH2-terminal kinase; ROS, reactive oxygen species; 4-HNE, 4-hydroxy-2-nonenal; DCF-DA, 2′,7′-dichlorofluorescein d
Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat
Keywords: 4-HNE، 4-hydroxy-2-nonenal; 8-OHdG, 8-hydroxy-2′-deoxyguanosin; 4-HNE, 4-hydroxy-2-nonenal; AGE, advanced end glycation products; TNF-α, tumor necrosis factor alpha; MCP-1, monocyte chemoattractant protein-1; MCA, middle cerebral artery; AM, amlodipine; AT, atorvastatinCerebral infa
Alzheimer's disease: Effects of β-amyloid on mitochondria
Keywords: 4-HNE، 4-hydroxy-2-nonenal; 4-HNE, 4-Hydroxy-2-nonenal; ABAD, β-amyloid binding alcohol dehydrogenase; AD, Alzheimer's disease; APP, Amyloid Precursor Protein; apoE, apolipoprotein E; LRP1, LDL receptor-related protein 1; AIF, apoptosis inducing factor; Drp-1, dynamin-related protei
SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells
Keywords: 4-HNE، 4-hydroxy-2-nonenal; CR, calorie restriction; FFA, free fatty acid; 4-HNE, 4-hydroxy-2-nonenal; MnSOD, manganese superoxide dismutase; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein-1; OCR, oxygen consumption rate; ROS, reactive oxygen species
Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation
Keywords: 4-HNE، 4-hydroxy-2-nonenal; Aldh, aldehyde dehydrogenases; 4-HNE, 4-hydroxy-2-nonenal; LPO, lipid peroxidation; MDA, malondialdehyde; WT, wild type; ORF, open reading frame; CYP, cytochrome P450; ROS, reactive oxygen species; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
Posttranslational modification and regulation of glutamate–cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal
Keywords: 4-HNE، 4-hydroxy-2-nonenal; 4-HNE, 4-hydroxy-2-nonenal; GCL, glutamate–cysteine ligase; GCLC, catalytic subunit of glutamate–cysteine ligase; GCLM, modifier subunit of glutamate–cysteine ligase; GST, glutathione S-transferase; GSH, glutathione; NEM, N-ethylmaleimide; NHS, sulfo-NHS-
Exposure to chrysotile asbestos causes carbonylation of glucose 6-phosphate dehydrogenase through a reaction with lipid peroxidation products in human lung epithelial cells
Keywords: 4-HNE، 4-hydroxy-2-nonenal; GSH, glutathione; G6PDH, glucose 6-phosphate dehydrogenase; DFO, deferoxamine; 4-HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; t-BHP, t-butylhydroperoxide; TBARS, thiobarbituric acid-r
Formation of acetaldehyde-derived DNA adducts due to alcohol exposure
Keywords: 4-HNE، 4-hydroxy-2-nonenal; AA, acetaldehyde; ADH, alcohol dehydrogenase; ALDH2, aldehyde dehydrogenase 2; CBI, covalent binding index; CRA, crotonaldehyde; CYP2E1, cytochrome P-450 2E1; dA, deoxyadenosine; dC, deoxycytidine; dG, deoxyguanosine; 4-HNE, 4-hydroxy-2-nonenal; HPLC-ECD,
Neuroprotective effects of 5-S-GAD against oxidative stress-induced apoptosis in RGC-5 cells
Keywords: 4-HNE، 4-hydroxy-2-nonenal; 4-HNE, 4-hydroxy-2-nonenal; 5-S-GAD, N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine; CM-H2DCFDA, 5,6-chloromethyl-2,7-dichlorodihydrofluorescein diacetate acetyl ester; DAB, 3-diaminobendizine tetrahydrochloride; FBS, fetal bovine serum; HBSS, Han
Periventricular white matter damage in the hypoxic neonatal brain: Role of microglial cells
Keywords: 4-HNE، 4-hydroxy-2-nonenal; 4-HNE, 4-hydroxy-2-nonenal; AMPA, amino-methyl-propionic-acid; CNS, central nervous system; CR3, complement type 3 receptors; CSF, cerebrospinal fluid; e NOS, endothelial nitric oxide synthase; ET-1, endothelin-1; ETs, endothelins; GLAST, glutamate aspart
Crucial role of peroxiredoxin III in placental antioxidant defense of mice
Keywords: 4-HNE، 4-hydroxy-2-nonenal; Prx, peroxiredoxin; qRT-PCR, quantitative real time polymerase chain reaction; LPS, lipopolysaccharide; ROS, reactive oxygen species; 4-HNE, 4-hydroxy-2-nonenal; Prepro-ET-1, prepro-endothelin 1; TNF-α, tumor necrosis factor alpha; PBS, phosphate-buffered
Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress
Keywords: 4-HNE، 4-hydroxy-2-nonenal; BSA, bovine serum albumin; BV, biliverdin; CBF, cerebral blood flow; CO, carbon monoxide; 4-HNE, 4-hydroxy-2-nonenal; MCA, middle cerebral artery; MCAO, MCA occlusion; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; PB, phosphate buffer; PBS, phosphate-buffered sali
Regulation of mitochondrial uncoupling respiration during exercise in rat heart: Role of reactive oxygen species (ROS) and uncoupling protein 2
Keywords: 4-HNE، 4-hydroxy-2-nonenal; Exercise; Heart; Mitochondria; Reactive oxygen species; Training; Uncoupling protein 2BSA, bovine serum albumin; DCF, dichlorofluorescein; DCFH-DA, dichlorofluorescin acetate; ETC, electron transport chain; 4-HNE, 4-hydroxy-2-nonenal; MnSOD, manganese sup
Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia
Keywords: 4-HNE، 4-hydroxy-2-nonenal; cAMP, cyclic adenosine monophosphate; DARPP-32, dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa; H&E, hematoxylin & eosin; HI, hypoxia-ischemia; HIE, hypoxic-ischemic encephalopathy; 4-HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; NMDA, N-methy
Aberrant expression of selenoproteins in the progression of colorectal cancer
Keywords: 4-HNE، 4-hydroxy-2-nonenal; ROS, reactive oxygen species; 4-HNE, 4-hydroxy-2-nonenal; 4-HHE, 4-hydroxy-2-hexenal; MDA, malonyldialdehyde; SOD-1, superoxide dismutase-1; GPx, glutathione peroxidase; TRX, thioredoxin; TXR, thioredoxin reductase; CAT, catalase; 8-OHdG, 8-hydroxy-2′-deo
Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats
Keywords: 4-HNE، 4-hydroxy-2-nonenal; FA, ferulic acid; ICAM-1, intercellular adhesion molecule-1; Mac-1, macrophage-1 antigen; 4-HNE, 4-hydroxy-2-nonenal; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; I/R, ischemia/reperfusionFerulic acid; Intercellular adhesion molecule-1 mRNA; Macrophage-1 antigen
An antioxidant effect by acyclic retinoid suppresses liver tumor in mice
Keywords: 4-HNE، 4-hydroxy-2-nonenal; ACR, acyclic retinoid; LCAD, long-acyl-CoA dehydrogenase; VLCAD, very long-acyl-CoA dehydrogenase; AOX, acly-CoA oxidase; CYP4a14, cytochrome p4504a14; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; 4-HNE, 4-hydroxy-2-nonenal; PCNA, proliferating cell nuclear antig
Protection of cardiomyocyte function by propofol during simulated ischemia is associated with a direct action to reduce pro-oxidant activity
Keywords: 4-HNE، 4-hydroxy-2-nonenal; CCT, creatine–carnitine–taurine; PBS, phosphate-buffered saline; FCS, fetal calf serum; MDA, malondialdehyde; 4-HNE, 4-hydroxy-2-nonenal; BSA, bovine serum albumin; PKC, protein kinase C; MLC, myosin light chain; MPTP, mitochondrial permeability transitio
Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice
Keywords: 4-HNE، 4-hydroxy-2-nonenal; BrdU, 5-bromo-2′-deoxyuridine; CCCP, carbonyl cyanide p-chlorophenylhydrazone; carboxy-DCFDA, (5-and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester; GST, glutathione transferase; 4-HNE, 4-hydroxy-2-nonenal; GPAT1, mitochondrial g
Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction
Keywords: 4-HNE، 4-hydroxy-2-nonenal; HF, heart failure; MI, myocardial infarction; ROS, reactive oxygen species; dP/dt, the maximal rate of left ventricular pressure; 8-OHdG, 8-hydroxydeoguanosine; 4-HNE, 4-hydroxy-2-nonenal; NADPH, nicotinamide adenosine dinucleotide phosphate; TUNEL, termi
The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (−/−) mice
Keywords: 4-HNE، 4-hydroxy-2-nonenal; GSH, reduced glutathione; GSTs, glutathione S-transferases; LPO, lipid peroxidation; 4-HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; GPx, glutathione peroxidase; DTNB, 5,5′-dithiobis(2-nitrobenzoicacid); CDNB, 1-chloro2,4 dinitrobenzene; ALT, alanine am
Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts
Keywords: 4-HNE، 4-hydroxy-2-nonenal; ALDH, aldehyde dehydrogenase; ALDH3A1, aldehyde dehydrogenase 3A1; UV, ultraviolet; 4-HNE, 4-hydroxy-2-nonenal; LPO, lipid peroxidation; MMC, mitomycin C; VP-16, etoposide; ROS, reactive oxygen species; GSSG, oxidized glutathione; GSH, reduced glutathione
Vitamins C and E attenuate apoptosis, β-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction
Keywords: 4-HNE، 4-hydroxy-2-nonenal; HF, heart failure; MI, myocardial infarction; GSH, reduced glutathione; GSSG, oxidized glutathione; dP/dt, the maximal rate of left ventricular pressure rise; 8-OHdG, 8-hydroxydeoguanosine; 4-HNE, 4-hydroxy-2-nonenal; TUNEL, terminal deoxynucleotidyl tran
Peroxyl radicals: Inductors of neurodegenerative and other inflammatory diseases. Their origin and how they transform cholesterol, phospholipids, plasmalogens, polyunsaturated fatty acids, sugars, and proteins into deleterious products
Keywords: 4-HNE، 4-hydroxy-2-nonenal; Aβ, amyloid β; AGE, advanced glycation end product; AMP, adenosine monophosphate; EI, electron impact; GC, gas chromatography; 8-HDG, 8-hydroxy-2′-deoxyguanosine; 4-HNE, 4-hydroxy-2-nonenal; L, dienyl radical; LDL, low-density lipoprotein(s); LG, levuglan