Keywords: 5-LOX، 5-lipoxygenase; 5-LOX, 5-lipoxygenase; CNS, central nervous system; COX, cyclooxygenase; CysLT1R, cysteinyl leukotriene receptor 1; CysLTs, cysteinyl leukotrienes; DA, dopaminergic; DAPI, 4′, 6-diamidino-2-phenylindole; DMEM, Dulbecco׳s modified Eagle׳s medium; ELISA, en
مقالات ISI 5-LOX، 5-lipoxygenase (ترجمه نشده)
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Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid
Keywords: 5-LOX، 5-lipoxygenase; 5-HETE, 5-hydroxyeicosatetraenoic acid; 5-LOX, 5-lipoxygenase; Bax, Bcl-2 Homolog X; Bcl-2, B-cell lymphoma-2; GFP, green fluorescent protein; GPCR, G protein-coupled receptors; IP3, inositol-3-phosphate; MT receptor, melatonin receptor; MTR, MitoTracker
The role of eicosanoids in 17α, 20β-dihydroxy-4-pregnen-3-one-induced ovulation and spawning in Danio rerio
Keywords: 5-LOX، 5-lipoxygenase; 5-HETE, 5-hydroxyeicosatetraenoic acid; 5-LOX, 5-lipoxygenase; 11-HETE, 11-hydroxyeicosatetraenoic acid; 12-HETE, 12-hydroxyeicosatetraenoic acid; 17,20βP, 17α, 20β-dihydroxy-4-pregnen-3-one; AA, arachidonic acid; COX, cyclooxygenase; COX-2, cyclooxygenas
OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells
Keywords: 5-LOX، 5-lipoxygenase; 5-Lox, 5-lipoxygenase; 5-oxoETE, 5-oxoeicosatetraenoic acid; GPCR, G protein-coupled receptor; OXER1, 5-oxoETE receptor; PLC-β, phospholipase C-beta; PKCε, protein kinase C-epsilon5-Lipoxygenase; Apoptosis; 5-OxoETE; OXER1; PLC-beta; PKC-epsilon
Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis
Keywords: 5-LOX، 5-lipoxygenase; 2010 DG, 2010 Dietary Guidelines for Americans; 5-Lox, 5-lipoxygenase; AA, arachidonic acid; AHA, American Heart Association; ALA, α-linolenic acid; AMDR, acceptable macronutrient distribution ranges; BMD, bone mineral density; CB2, cannabinoid receptor t
Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells
Keywords: 5-LOX، 5-lipoxygenase; 5-LOX, 5-lipoxygenase; NF-κB, nuclear factor κB; IκB, inhibitor κB; LTB4, leukotriene B45-LOX; NF-κB; Hepatocellular carcinoma; Transcriptional activity; Leukotriene B4
The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo
Keywords: 5-LOX، 5-lipoxygenase; 5-HETE, 5-hydroxy-eicosa-tetra-enoic acid; LTB4, leukotriene B4; 12-HHT, 12-hydroxyheptadeca-5, 8, 10-trienoic acid; PGB2, prostaglandin B2; PGF2α, prostaglandin F2α; 5-LOX, 5-lipoxygenase; COX-2, cyclooxygenase-2; TNF-α, tumor necrosis factor-alpha; LPO,
Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats
Keywords: 5-LOX، 5-lipoxygenase; BSO, buthionine sulfoximine; DAZ, dazmegrel; DEC, diethylcarbamazine; DEM, diethyl maleate; 5-(S)-HPETE, 5-(S)-hydroperoxyeicosatetraenoic acid; INDO, indomethacin; 5-LOX, 5-lipoxygenase; LTA4 (C4, D4, E4), leukotriene A4 (C4, D4, E4); NDHS, N-(3,5-dichlo
Exposure to nerve agents: From status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy
Keywords: 5-LOX، 5-lipoxygenase; 5-LOX, 5-lipoxygenase; BBB, blood brain barrier; BChE, butyrylcholinesterase; BDNF, brain-derived neurotrophic factor; CA1, Cornus Ammonis or Ammon's Horn Subfield 1; CA3, Cornus Ammonis or Ammon's Horn Subfield 3; COX, cyclooxygenase; COX-2, cyclooxygena
Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide
Keywords: 5-LOX، 5-lipoxygenase; CEES, 2-chloroethyl ethyl sulfide; COX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; GST, glutathione S-transferase; mGST, microsomal GST; LTA4, leukotriene A4; LTC4, leukotriene C4; 5-LOX, 5-lipoxygenase; FLAP, 5-LOX activating protein; 8-LOX, 8-lipoxyge
Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
Keywords: 5-LOX، 5-lipoxygenase; CEES, 2-chloroethyl ethyl sulfide; COX-2, cyclooxygenase-2; GST, glutathione S-transferase; LTA4, leukotriene A4; LTC4, leukotriene C4; 5-LOX, 5-lipoxygenase; FLAP, 5-LOX activating protein; phospho-H2AX, phosphorylated histone H2AX; (PARP), poly(ADP-ribo
Chebulagic acid, a COX–LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line
Keywords: 5-LOX، 5-lipoxygenase; μg, micro gram; μm, micrometers; μM, micro molar; °C, degree centigrade/degree Celsius; 5-LOX, 5-lipoxygenase; AA, arachidonic acid; ABTS, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid); COX, cyclooxygenase; DPPH, 2,2′-diphenyl-1-picrylhydrazyl; E
Aegiceras corniculatum extract suppresses initial and late phases of inflammation in rat paw and attenuates the production of eicosanoids in rat neutrophils and human platelets
Keywords: 5-LOX، 5-lipoxygenase; AA, arachidonic acid; COX, cyclooxygenase; PLA2, phospholipase A2; 5-,12-HETE, hydroxyeicosatetraenoic acid; 12-HHT, 12-hydroxyheptadecatrienoic acid; 5-LOX, 5-lipoxygenase; LT, leukotriene; NDGA, nordihydroguaiaretic acid; NSAIDs, non-steroidal anti-infl
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity
Keywords: 5-LOX، 5-lipoxygenase; GSE, grape seed extract; 5-LOX, 5-Lipoxygenase; MβCD, methyl-β-cyclodextrin; NBD cholesterol, 22-(N-(7 nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-23,24-bisnor-5-cholen-3β-ol; RWPC, red wine polyphenolic compounds; SDS, sodium dodecyl sulfate.Polyphenols; Red
Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines
Keywords: 5-LOX، 5-lipoxygenase; TL, triptolide; 5-LOX, 5-lipoxygenase; LTB4, leukotriene B4Triptolide; Pancreatic tumor; 5-lipoxygenase; Caspase-3; Bcl-2
Baicalin attenuates oxygen–glucose deprivation-induced injury via inhibiting NMDA receptor-mediated 5-lipoxygenase activation in rat cortical neurons
Keywords: 5-LOX، 5-lipoxygenase; OGD, oxygen–glucose deprivation; 5-LOX, 5-lipoxygenase; GFP-5-LOX, green fluorescence protein-5-lipoxygense; CysLTs, cysteinyl leukotrienes; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; EIA, enzyme immunoassay; NMDA, N-methyl-d-aspa
Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae)
Keywords: 5-LOX، 5-lipoxygenase; ACN, acetonitrile; COX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; EtAc, ethyl acetate; 5-HETE, 5-hydroxyeicosatetraenoic acid; HepG2, human Caucasian hepatocyte carcinoma; HPLC, high-performance liquid chromatography; 5-LOX, 5-lipoxygenase; NSAIDs, non