Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency
Keywords: 7 هیدروکسی 4-تری فلووریمتیکومارین; Cytochrome P450 3A4; Allostery; Progesterone; Testosterone; Coupling; Heme spin-state; BFC; 7-benzyloxy-4-trifluoromethylcoumarin; CPR; cytochrome P450 reductase; CYP3A4; human cytochrome P450 3A4; DTT; 1,4-dithiothreitol; HFC; 7-hydroxy-4-trifluoromethyl