Keywords: AC، adenylyl cyclase; 5-HT, 5-hydroxytryptamine; AC, adenylyl cyclase; ADHD, attention deficit hyperactivity disorder; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; cAMP, 3′,5′-cyclic adenosine monophosphate; DA, dopamine; DAT, dopamine transporter; dlPFC, dorsol
مقالات ISI AC، adenylyl cyclase (ترجمه نشده)
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Keywords: AC، adenylyl cyclase; ABCC1, ATP-binding cassette (ABC) transporter; AC, adenylyl cyclase; AEA, anandamide; AKt, protein kinase B; AM251, a CB1 receptor antagonist; AM630, a CB2 receptor antagonist; AMPK, 5′-adenosine monophosphate-activated protein kinase; ATF-4, activating t
Keywords: AC، adenylyl cyclase; 2-AG, 2-arachidonoyl-glycerol; 2-MAGs, monoacylglycerols; 2-OG, 2-oleoyl-glycerol; Abhd4, α/β-hydrolase domain type-4; ABHD6 and 12, α/β-Hydrolase Domain Containing Protein 6 and 12; AC, adenylyl cyclase; AD, Alzheimer's disease; AEA, N-arachidonoyl-ethan
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; mAC, mammalian adenylyl cyclase; tmAC, transmembrane mammalian adenylyl cyclase; sAC, soluble adenylyl cyclase; 2′,5′-dd-3′-ATP, 2′,5′-dideoxy-3′-adenosine triphosphate; PPi, pyrophosphate; cAMP, cyclic adenosine monophosphateCrystal
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; BLUF, blue light-sensing using FAD; FAD, flavin adenine dinucleotide; FMN, flavin mononucleotide; LOV, light oxygen voltage (protein domain); mPAC, photoactivated AC from Microcoleus chthonoplastes; YFP, yellow fluorescent proteinCyc
Keywords: AC، adenylyl cyclase; ASICs, acid-sensing ion channels; DRG, dorsal root ganglion; IpH, proton-gated current; TRPV1, transient receptor potential vanilloid type 1; PKA, protein kinase A; AC, adenylyl cyclase; 8-Br-cAMP, 8-bromo-cAMP; DAMGO, [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephali
Keywords: AC، adenylyl cyclase; AA, arachidonic acid; ABP, androgen binding protein; AC, adenylyl cyclase; A-GSU, A-glycoprotein subunit; AP1, activator protein1; AR, androgen receptors; ARC, arcuate nucleus; ATF, activating transcription factor; CAMK, Ca2 +-calmodulin kinase; CREB, cAM
Keywords: AC، adenylyl cyclase; ABTS, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt; AC, adenylyl cyclase; cAMP, adenosine 3′,5′-cyclic monophosphate; 6-Cl-PuDP, 6-chloro purine 5′ diphosphate; DMSO, dimethyl sulfoxide; ERK, extracellular signal regulated kinase
Polypharmacology of dopamine receptor ligands
Keywords: AC، adenylyl cyclase; ACh, acetylcholine; AC, adenylyl cyclase; APO, apomorphine; PD, Parkinson’s disease; CNS, central nervous system; COMT, catecholamine O-methyl transferase; DML, designed multiple ligands; L-DOPA, L-3,4-dihydroxyphenylalanine; LID, L-DOPA induced dyskinesi
The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; cAMP, cyclic AMP; CNS, central nervous system; CoCl2, cobalt chloride; DMEM, Dulbecco's Modified Eagle's Medium; ERK, extracellular signal-regulated kinase; FK506, tacrolimus; GFAP, glial fibrillary acidic protein; GHRH, growth hormo
Distinct regions in the C-Terminus required for GLP-1R cell surface expression, activity and internalisation
Keywords: AC، adenylyl cyclase; Glucagon like peptide-1 (GLP-1); GLP-1 receptor (GLP-1R); G protein coupled receptor (GPCR); Biosynthetic trafficking; C-terminus; Diabetes5-HT2a, 5-hydroxytryptamine receptor 2a; aa, amino acid; AC, adenylyl cyclase; AR, adrenoceptor; ARF1, ADP-ribosylat
Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; AD, Alzheimer's disease; CaM, calmodulin; CaM-mut, mutant calmodulin species; CaM-wt, wild-type calmodulin; CD, circular dichroism; DTT, dithiothreitol; EGTA, ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid; H2O2, h
Soluble adenylyl cyclase of sea urchin spermatozoa
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; AR, acrosome reaction; CaM, calmodulin; cAMP, cyclic adenosine monophosphate; LD-DIM, low density detergent-insoluble membranes; PKA, cAMP dependent protein kinase; RACE, rapid amplification of cDNA ends; sAC, soluble adenylyl cyclas
Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; ApCpp, α,β-methylene-adenosine-5′-triphosphate; ATPαS, adenosine-5′-α-thio-triphosphate; CE, catechol estrogen; DIDS, 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid; Gβγ, G protein, β and γ subunits; GC, guanylyl cyclase; Gsα, st
5HT1B receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula
Keywords: AC، adenylyl cyclase; Epithalamus; Serotonin; EPSCs; Patch clamp; Synaptic plasticity4AP, 4-aminopyridine; 5-CT, 5-carboxyamidotryptamine; 5HT, 5-hydroxytryptamine; 8-OH-DPAT, 8-hydroxy-2-(di-n-propylamino)tetralin; AC, adenylyl cyclase; aCSF, artificial cerebrospinal fluid; C
α-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function
Keywords: AC، adenylyl cyclase; cAMP, 3′5′ cyclic adenosine monophosphate; IL, interleukin; RANTES, Normal T cell Expressed and Secreted; PBMC, peripheral blood mononuclear cell; GPCR, G-protein coupled receptor; AC, adenylyl cyclase; PKA, protein kinase A; NK, natural killer; Th, T hel
Re-invigorating the insecticide discovery pipeline for vector control: GPCRs as targets for the identification of next gen insecticides
Keywords: AC، adenylyl cyclase; AaDOP, Aedes aegypti dopamine receptor; AC, adenylyl cyclase; ADD, Academic Drug Discovery center; cAMP, cyclic AMP; CRC, concentration response curve assay; DAR, dopamine receptor; DHX, dihydrexidine; EC, effective concentration; FDA, Food and Drug Admin
Gene transfer for congestive heart failure: update 2013
Keywords: AC، adenylyl cyclase; AAV, adeno-associated virus; AC, adenylyl cyclase; AC6, adenylyl cyclase 6; βAR, β-adrenergic receptor; CHF, congestive heart failure; CMV, cytomegalovirus; GRK2, G-protein-coupled receptor kinase 2; LV, left ventricular; IC, intracoronary; SR, sarcoplasm
Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; BSA, bovine serum albumin; CB1R, cannabinoid type-1 receptor; CB2R, cannabinoid type-2 receptor; CHO-hCB2, CHO cells expressing human CB2Rs; Δ9-THC, delta-9-tetrahydrocannabinol; FRO, fractional receptor occupancy; GDP, guanosine dip
CCL5-glutamate interaction in central nervous system: Early and acute presynaptic defects in EAE mice
Keywords: AC، adenylyl cyclase; Glutamate release; CCL5; EAE mice; cAMP; Spinal cord; Cortex[3H]D-ASP, [3H]d-aspartate; AC, adenylyl cyclase; cAMP, cyclic adenosine monophosphate; CD45, cluster of differentiation 45; CNS, central nervous systems; CSF, cerebrospinal fluid; d.p.i., days p
Modulation of striatal neuron activity by cyclic nucleotide signalling and phosphodiesterase inhibition
Keywords: AC، adenylyl cyclase; cAMP, adenosine 3′-5′-cyclic monophosphate; ATP, adenosine triphosphate; AC, adenylyl cyclase; ADSD, autosomal-dominant striatal degeneration; CREB, cAMP response element binding protein; PKA, cAMP-dependent protein kinase; PKG, cGMP-dependent protein kin
Acute up-regulation of the rat brain somatostatin receptor-effector system by leptin is related to activation of insulin signaling and may counteract central leptin actions
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; BSA, bovine serum albumin; CRE, cyclic AMP response element; CREB, CRE binding protein; EDTA, ethylenediaminetetraacetic acid; ELISA, enzyme-linked immunosorbent assay; FK, forskolin; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfo
Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; PDE, phosphodiesterase; PHD, prolyl hydroxylase domain protein; H9c2 cells, a cell line derived from embryonic rat heart; SDS, sodium dodecyl sulfate; PAGE, polyacrylamide gel electrophoresiscAMP; Prolyl hydroxylase domain protein; A
Evidence for cAMP-independent bTREK-1 inhibition by ACTH and NPS-ACTH in adrenocortical cells
Keywords: AC، adenylyl cyclase; AZF, adrenal zona fasciculatata; AZG, adrenal zona glomerulosa; AC, adenylyl cyclase; 2,5-dd-3′-ATP, 2,5-dideoxyadenosine-3′-triphosphate; FBS, fetal bovine sera; NPS-ACTH, O-nitrophenyl-adrenocorticotropinAdrenal; ACTH; TREK-1 K+ channel; cAMP
Corticotropin-releasing hormone stimulates mitotic kinesin-like protein 1 expression via a PLC/PKC-dependent signaling pathway in hippocampal neurons
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; AMPAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CNS, central nervous system; CRH, corticotrophin-releasing hormone; CRMP3, collapsin response mediator protein 3; FBS, fetal bovine serum; FITC, fluorescein isothi
Functional status and relationships of melanocortin 1 receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells
Keywords: AC، adenylyl cyclase; Rp-cAMPS, adenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer; AC, adenylyl cyclase; db-cAMP, dibutyryl-cAMP; 8-CPT, 8-(4-chlorophenylthio)-2′-O-methyl-cAMP; DDA, 2′,5′-dideoxyadenosine; GPCR, G protein-coupled receptor; MC1R, melanocortin 1 receptor;
Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: Comparison with membranous adenylyl cyclase I
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; AC1, membranous adenylyl cyclase isoform 1; CyaA, Bordetella pertussis adenylyl cyclase toxin; CaM, calmodulin; CaM-WT, wild-type calmodulin; FRET, fluorescence resonance energy transfer; 2′-MANT-3′-d-ATP, 2′-(N-methylanthraniloyl)-3
Characterization of a Ca2+/calmodulin-dependent AC1 adenylyl cyclase in a non-neuronal tissue, the blowfly salivary gland
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; [Ca2+]free, free Ca2+ concentration; [Ca2+]i, intracellular free Ca2+ concentration; CaM, calmodulin; cAMP, cyclic adenosine 3′,5′-monophosphate; [cAMP]i, intracellular concentration of cAMP; CHD, cyclase-homology domain; CsA, cyclos
The distribution of low-threshold TTX-resistant Na+ currents in rat trigeminal ganglion cells
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; ACSF, artificial cerebral spinal fluid; A-D/D-A, analog to digital/digital to analog; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; DiI, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine iodide; DRG, dorsal
The genetics of selective serotonin reuptake inhibitors
Keywords: AC، adenylyl cyclase; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTT, 5-hydroxytryptamine transporter, serotonin transporter; 5-HTTLPR, 5-hydroxytryptamine transporter-linked polymorphic region; AC, adenylyl cyclase; ACTH, adrenocorticotropic hormone; AMPA, α-amino-3-hydroxy-5-me
Roles of Ca2+ and cyclic nucleotide gated channel in plant innate immunity
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; AtSR1, Arabidopsis signal responsive 1; BcPG1, Botrytis cinerea elicitor endopolygalacturonase 1; cADPR, cyclic ADP ribose; CaM, calmodulin; CAMTA, CaM-binding transcription activator; CBP, CaM binding protein; CDPK, Ca2+-dependent p
Adenosine receptors and vascular inflammation
Keywords: AC، adenylyl cyclase; AC, Adenylyl cyclase; ACh, Acetylcholine; ADA, Adenosine deaminase; AD, Adenosine; ADP, Adenosine diphosphate; AR, Adenosine receptor; AK, Adenosine kinase; AMP, Adenosine monophosphate; BAL, Bronchoalveolar lavage; cAMP, Cyclic adenosine monophosphate; C
Roles of prostaglandin E2 in the cochlea
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; AA, arachidonic acid; cAMP, cyclic adenosine monophosphate; COX, cyclooxygenase; COX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; DAG, diacylglycerol; EP, E-prostanoid receptor; IP3, inositol-1,4,5-trisphosphate; MRP4, multidrug res
Pharmacological evidence that Ca2+ channels and, to a lesser extent, K+ channels mediate the relaxation of testosterone in the canine basilar artery
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; cAMP, 3′,5′-cyclic adenosine monophosphate; cGMP, 3′,5′-cyclic guanosine monophosphate; DMSO, dimethyl sulfoxide; GC, guanylyl cyclase; ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; SNP, sodium nitroprusside; SQ 22,536, [9-(tetra
Purinergic mechanisms in gliovascular coupling
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; ASM, arteriolar smooth muscle; BBG, brilliant blue G; BKCa, large-conductance, Ca2+-operated K+ channel; CBF, cerebral blood flow; COX, cyclo-oxygenase; Cx43, connexin 43; EET, epoxyeicosatrienoic acid; e-NPP, ecto-pyrophosphatase/ph
Isoforskolin pretreatment attenuates lipopolysaccharide-induced acute lung injury in animal models
Keywords: AC، adenylyl cyclase; AA, arachidonic acid; AC, adenylyl cyclase; ALI, acute lung injury; ARDS, acute respiratory distress syndrome; BALF, bronchoalveolar lavage fluid; cAMP, cyclic adenosine monophosphate; CI, chemotactic index; DEX, dexamethasone; fMLP, formylmethionyl leucy
Rescuing the Failing Heart by Targeted Gene Transfer
Keywords: AC، adenylyl cyclase; calcium; gene therapy; heart failure; sarcoplasmic reticulumAAV, adeno-associated virus; AC, adenylyl cyclase; β-AR, beta-adrenergic receptor; GRK, G protein–coupled receptor kinase; HF, heart failure; LV, left ventricular; PLN, phospholamban; PP1, protei
Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3
Keywords: AC، adenylyl cyclase; 7TM, seven-transmembrane; AC, adenylyl cyclase; Bmax, maximal binding capacity; BSA, bovine serum albumin; β2-AR, β2-adrenergic receptor; CHO, Chinese Hamster Ovary; CT, cytoplasmic tail; D1R, dopamine D1 receptor; D2R, dopamine D2 receptor; DA, dopamine;
A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels
Keywords: AC، adenylyl cyclase; 2-AG, 2-arachidonoylglycerol; 12-HPETE, 12-hydroperoxyeicosatetraenoic acid; AA, arachidonic acid; ABHD, α/β-hydrolase domain; AC, adenylyl cyclase; anandamide, N-arachidonoylethanolamine (aka arachidonoyl ethanolamide or AEA); ARC channel, arachidonate-r
The H2-receptor antagonist ranitidine interferes with clopidogrel-mediated P2Y12 inhibition in platelets
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; ASA, acetylsalicylic acid; CAD, coronary artery disease; DAT, dual antiplatelet therapy; EMEA, European Medicines Agency; FDA, Food and Drug Administration; P2Y12, ADP receptor P2Y12; PCI, percutaneous coronary interventions; PGE1, p
Identification of hippocampus-dependent and hippocampus independent memory components in step-down inhibitory avoidance tasks
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; aCSF, artificial cerebrospinal fluid; FK, forskolin; FK 3H mice, mice injected with forskolin in the hippocampus 3 h after the acquisition; HIPP mice, mice with a bilateral lesion of the hippocampus; I.A., inhibitory avoidanceContext
Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells
Keywords: AC، adenylyl cyclase; cAMP, cyclic adenosine monophosphate; Treg, regulatory T cells; Tcon, conventional T cells; PDE, phosphodiesterase; AC, adenylyl cyclase; IL-2, interleukin-2; mAbs, monoclonal Abs; ddADO, 2′,3′-dideoxy-adenosine; Dip, DipyridamoleCyclic adenosine monophos
Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; ANOVA, analysis of variance; βAR, β-adrenergic receptor; m2AChR, m2-muscarinic acetylcholine receptor; OP, organophosphateAdenylyl cyclase; β-Adrenergic receptor; Cyclic AMP; Heart development; High-fat diet; Liver development; Musca
Spatiotemporal control of cyclic AMP immunomodulation through the PKA–Csk inhibitory pathway is achieved by anchoring to an Ezrin–EBP50–PAG scaffold in effector T cells
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; AKAP, A kinase anchoring protein; APC, antigen presenting cell; cAMP, cyclic adenosine monophosphate; Cbp, Csk binding protein; Csk, C-terminal Src kinase; EBP50, Ezrin/radixin/moesin (ERM) binding protein of 50 kDa; Gads, Grb-relate
Role of CREB in modulation of TNFα and IL-10 expression in LPS-stimulated RAW264.7 macrophages
Keywords: AC، adenylyl cyclase; PKA, protein kinase A; β-AR, β-adrenergic receptor; GPCR, G protein-coupled receptor; AC, adenylyl cyclase; PVDF, Immobilon-FL polyvinylidene fluoride; TLR, toll-like receptor; LPS, lipopolysaccharide; TNF, tumor necrosis factor; IL, interleukinCREB; LPS;
Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; ANOVA, analysis of variance; CPF, chlorpyrifos; DZN, diazinon; PRT, parathion; NGF, nerve growth factor; OP, organophosphateAdenylyl cyclase; Chlorpyrifos; Diazinon; Organophosphate insecticide; Parathion
Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; cAMP, cyclic adenosine monophosphate; dATP, desoxy adenosine triphosphate; DA, dopamine; D1, dopamine 1 receptor; D2, dopamine 2 receptor; KO, knock-out; MOR, μ-opioid receptor; mRNA, messenger ribonucleic acid; MSN, medium spiny neu
Glutamate differently modulates excitatory and inhibitory adenosine receptors in neuronal and glial cells
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; ADA, adenosine deaminase; AraC, cytosine β-d-arabinofuranoside; CHA, cyclohexyladenosine; CGS 21680, 2-[p-(2-carboxyethyl) phenylamino]-5′-N-ethylcarboxyamide adenosine; CPA, cyclopentyladenosine; DPCPX, 8-cyclopentyl-1,3-dipropylxan
The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation
Keywords: AC، adenylyl cyclase; AC, adenylyl cyclase; Akt, protein kinase B; ARDS, acute respiratory distress syndrome; BAPTA-AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); cAMP, cyclic adenosine 3′,5′-monophosphate; CB, cytochalasin B; COPD,
Thy-1 mRNA destabilization by norepinephrine a 3′ UTR cAMP responsive decay element and involves RNA binding proteins
Keywords: AC، adenylyl cyclase; T cells; Cell surface molecules; Thy-1; Neuroimmunology; Signal transduction; mRNA regulation; RNA binding proteins; HuRCA, catecholamine; NE, norepinephrine; βAR, beta-adrenergic receptor; AC, adenylyl cyclase; ARE, AU-rich element; AREbp, ARE binding pr