دانلود مقالات ISI درباره Ada, Anti-Drug Antibody + ترجمه فارسی

مدیریت ایمنی زیستی ناخواسته بیولوژیکی

Managing unwanted immunogenicity of biologicals

Keywords: ADA, anti-drug antibody; DC, dendritic cells; EIP, European Immunogenicity Platform; FcγR, Fc gamma receptor; FDA, Food and Drug Administration; HLA, human leukocyte antigen; IBD, inflammatory bowel diseases; IFN, interferon; IVIG, intravenous immunoglobu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

مقایسه سیستم های مبتنی بر سلول های مبتنی بر سلول های مبتنی بر سلول ها برای تشخیص آنتی بادی ضد عفونی کننده ضد حساسیت بالینی برای ارزیابی ایمنی زایی پروتئین های درمانی

Comparison of cell-based and non-cell-based assay platforms for the detection of clinically relevant anti-drug neutralizing antibodies for immunogenicity assessment of therapeutic proteins

Keywords: ADA, anti-drug antibody; MAb, monoclonal antibody; NAb, neutralizing antibody; CLB, competitive ligand binding; MRD, minimal required dilution; PC, positive control; PHS, pooled human serum; MAb, monoclonal antibody; IC50, half of maximal inhibitory conce

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

افزایش کارایی و کیفیت برآورد آماری نقاط برش از طریق ایمنی زایی از طریق استاندارد سازی و اتوماسیون

Enhancing efficiency and quality of statistical estimation of immunogenicity assay cut points through standardization and automation

Keywords: ADA, anti-drug antibody; CAST, customized assay statistical tool; ACP, screening assay cut point; DCP, depletion cut point; ECL, electrochemiluminescence; S/N, signal to noise ratio; NC, negative control; NAb, neutralizing antibody; Log, logarithm; ANOVA,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Epitope characterization of the ADA response directed against a targeted immunocytokine

Keywords: ADA, anti-drug antibody; Bi, biotin; CCP, competition cut point; CDRs, complementary-determining regions; CP, cut point; Cy, cytokine; Dig, digoxigenin; DCA, domain competition assay; DDA, domain detection assay; HRP, horse radish peroxidase; KD, dissocia

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Systematic comparison of drug-tolerant assays for anti-drug antibodies in a cohort of adalimumab-treated rheumatoid arthritis patients

Keywords: ADA, anti-drug antibody; ADL, adalimumab; ABT, antigen binding test; PIA, pH-shift-anti-idiotype Antigen binding test; ARIA, Acid-dissociation RadioImmunoAssay; TRIA, Temperature-shift RadioImmunoAssay; ECL, electrochemoluminescenceAnti-drug antibodies (A

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis)

Keywords: ADA, anti-drug antibody; AUC, area under the concentration–time curve; Cmax, maximum concentration in plasma; EDTA, ethylenediaminetetraacetic acid; DB, day after birth; ELISA, enzyme-linked immunosorbent assays; ePPND, enhanced pre- and postnatal develop

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a biosensor-based immunogenicity assay capable of blocking soluble drug target interference

Keywords: ADA, anti-drug antibody; Ang1, angiopoietin-1; Ang2, angiopoietin-2; ECL, electrochemiluminescence; Ig, immunoglobulin; ka, association rate constant; kd, dissociation rate constant; KD, affinity constant; MSD, Meso Scale Discovery; RU, response unit; S/N

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Recommendations for the validation of cell-based assays used for the detection of neutralizing antibody immune responses elicited against biological therapeutics

Keywords: ADA, anti-drug antibody; NAb, neutralizing antibody; FDA, Food and Drug Administration; EMEA, European Medicines Agency; ICH, International Conference on Harmonization; PC, positive control; LPC, low positive control; HPC, high positive control; SD, stand

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Recommendations for the validation of flow cytometric testing during drug development: II assays

Keywords: AAPS, American Association of Pharmaceutical Scientists; ADA, anti-drug antibody; 7-AAD, 7-aminoactinomycin; CLIA, Clinical Laboratory Improvement Amendments; CLSI, Clinical and Laboratory Standards Institute; CMS, Centers for Medicare & Medicaid Services

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

A novel gamma-fitting statistical method for anti-drug antibody assays to establish assay cut points for data with non-normal distribution

Keywords: ADA, anti-drug antibody; ATA, anti-therapeutic antibody; CP, cut point; NAB, neutralizing antibody; CF, cut point correction factor; NC, negative control; EDF, empirical distribution function-type statistical tests of normality; MLE, maximum likelihood es

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Isolation of human anti-idiotypic antibodies by phage display for clinical immune response assays

Keywords: pK, pharmacokinetics; IR, immune response; Ab, antibody; mAb, monoclonal antibody; ADA, anti-drug antibody; IgG, immunoglobulin; λ, lambda light chain of an antibody; κ, kappa light chain of an antibody; VH, variable region of the heavy chain of an antibo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه