Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; HRMS, high-resolution mass spectrometry; UPLC-LTQ-Orbitrap, ultra-high-performance liquid chromatography coupled with a linear ion trap-Orbitrap mass spectrometer; SD, Sprague-Dawley; EIC, extracte
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Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; ROS, reactive oxygen species; MDA, malondialdehyde; OATP, organic anion transporting polypeptide; QQ, quercetin–quinone; GSH, glutathione; RLE, rat lung epithelial cells; LDH, lactate dehydrogenase
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; BBD, benign breast disease; BMI, body-mass index; CRP, C-reactive proteins; CV, coefficient of variation; CI, confidence interval; DNA, deoxyribonucleic acid; 8-iso-PGF2α, 8-iso-prostaglandin F2α;
Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography–tandem ICP-mass spectrometry (HPLC–ICP-MS/MS)
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; API, active pharmaceutical ingredient; LC-UV, high performance liquid chromatography with UV-detection; LC–MS(/MS), high performance liquid chromatography–(tandem) mass spectrometry; CE–MS, capilla
From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; bw, body weight; E2, 17β-estradiol; EDC, endocrine disruptive chemical; EGFR, epidermal growth factor receptor; ERE, estrogen response element; ERE-luc, ERE-luciferase; GNX, gonadiectomized; LUMA,
Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; AB, apical-to-basolateral; ABC, ATP-binding cassette; ABCB1, P-glycoprotein; ABCC1, multidrug resistance-associated protein 1; ABCG2, breast cancer resistance protein; ADME, absorption, distribution, metabolism and excretion; BA, basolateral-to-apical; CD
cIEF for rapid pKa determination of small molecules: A proof of concept
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; CA, carrier ampholytes; CE, capillary electrophoresis; cIEF, capillary isoelectric focusing; EOF, electroosmotic flow; FS, fused silica; HPC, hydroxypropylcellulose; pI, isoelectric point; pKa, ion
Cyclosporin A affects the bioavailability of ginkgolic acids via inhibition of P-gp and BCRP
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; BBB, blood–brain barrier; BCRP, breast cancer resistant protein; CsA, Cyclosporin A; DMEM, Dulbecco’s modified Eagle’s medium; GA, ginkgolic acid; HBSS, Hanks’ balanced salt solution; IS, internal
Recent progress in the identification of BRAF inhibitors as anti-cancer agents
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; BRAF; Inhibitors; Anti-cancer agentsabl, abelson murine leukemia viral oncogene homolog 1; ADME, absorption, distribution, metabolism and excretion; CR, conserved regions; CRD, cysteine-rich domain, DFG, D594, F595, and G596; ELISA, enzyme-linked immunoso
Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; AUC, area under curve; Cmax, maximum plasma concentration; DGM, desglymidodrine; FaSSIF, fasted-state simulated intestinal fluid; HIF, human intestinal fluid; IVIVE, in vitro–in vivo extrapolation;
A mechanistic approach for modeling oral drug delivery
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; CAT, compartmental absorption and transit; AUC, area under the curve; GI, gastrointestinal; ADME, absorption, distribution, metabolism and excretion; NSC, normalized sensitivity coefficient; ACAT, advanced compartmental and transit; Cmax, peak plasma conc
Advances in nanomedicines for malaria treatment
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; μTAS, Micro analysis systems; ACT, artemisin combination therapy; ADME, absorption, distribution, metabolism and excretion; Ag NPs, silver nanoparticles; AUC, area under the plasma level-time curve; AFM, atomic force microscopy; CCRD, central composite ro
Novel bis-(−)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; AD, Alzheimer's disease; Aβ, amyloid-β; AChE, acetylcholinesterase; AChEIs, acetylcholinesterase inhibitors; ADME, absorption, distribution, metabolism and excretion; ROS, reactive oxygen species; ACh, acetylcholine; MEP, meptazinol; LAH, lithium aluminum
Preclinical experimental models of drug metabolism and disposition in drug discovery and development
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; AO, aldehyde oxidases; AUC, area under the plasma concentration–time course curve; BCRP, breast cancer resistance protein; BDC, bile-duct cannulation; BSEP, bile salt export pump; CYP, cytochrome P
Pharmaceutical therapies to recode nonsense mutations in inherited diseases
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; 2-DOS, 2-deoxystreptamine; 6MWD, 6-minute walk test; aa-tRNA, aminoacyl-tRNA; ADME, absorption, distribution, metabolism and excretion; AHC, anterior horn cell; ALT, alanine aminotransferase; A-T, ataxia-telangiectasia; ATM, A-T mutated; BBB, blood–brain
Novel strategies for microdose studies using non-radiolabeled compounds
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; AMS, accelerator mass spectrometry; AUC, area under the plasma concentration–time curve; BSEP, bile salt export pump; Cmax, maximum plasma concentration; CYP, cytochrome P450; DIN, drug interaction
Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; ATP, adenosine triphosphate; AUC (0–24 h), area under the plasma concentration curve from 0 to 24 h; b.i.d., twice daily; cGMP, cyclic guanosine monophosphate; Cmax, maximum plasma concentration; C
Recent advances in applications of liquid chromatography–tandem mass spectrometry to the analysis of reactive drug metabolites
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; CNLS, constant neutral loss scan; CYP, cytochrome P450; EPI, enhanced product ion; FTICRMS, Fourier transform ion cyclotron resonance mass spectrometry; GSH, glutathione; GSH-EE, glutathione ethyl
Can systems toxicology identify common biomarkers of non-genotoxic carcinogenesis?
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; GTX, genotoxic; NCE, novel chemical entity; NGTX, non-genotoxic; N-GTX, non-carcinogenic; PPARα, peroxisome proliferator activated receptor alpha; PXR, pregnane X-receptorSystems toxicology; Non-ge
Pharmacokinetics and bioavailability of diisopropanolamine (DIPA) in rats following intravenous or dermal application
Keywords: ADME، جذب، توزیع، متابولیسم و دفع; ADME, absorption, distribution, metabolism and excretion; AUC, areas under the plasma concentration time curve; DEA, diethanolamine; DIPA, diisopropanolamine; ECB, European commission – European chemicals bureau; HCl, hydrochloric acid; HPLC, high perform