دانلود مقالات ISI درباره Adme-Tox + ترجمه فارسی

اکتشاف مشتقات پریرول برای پیدا کردن یک مسدود کننده اسید پتاسیم موثر با فشار ناگهانی در معرض ترشح اسید معده

Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion

Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; AUC; area under the curve; BnSH; benzyl mercaptan; Xantphos; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

شناسایی یک مشتق از فلوروپیرلل جدید به عنوان یک مسدود کننده اسید پتاسیم رقابتی با طولانی مدت فعالیت

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action

Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3A4; DSC; differential scanning calorimetry; DIBAL-H; diisobutylaluminium hydride; DME; 1,2-dimethoxyethane; DM

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

فعالیت ضد توموری مشتقات اسید چرب 1،2،3-تریاازول

Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives

Keywords: 1,2,3-triazoles; Tuberculosis; Resistant strains; Parallel solution synthesis; SAR; ADME-tox;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies

Keywords: Cell-based assay; Organs-on-a-chip; ADME-Tox; Drug discovery; Safety assessment; Standardization; Inter-organ network; Enterohepatic circulation; Gut-liver axis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo

Keywords: Hedgehog inhibitor; In vivo pharmacokinetics; Gram-scale synthesis; ADME-Tox; LS180 xenograft; Acylguanidine; Hh; Hedgehog; Shh; Sonic Hedgehog; Ptch; Patched; Smo; Smoothened; BCC; basal cell carcinoma; PE; petroleum ether; SRB; sulforhodamine B; Shh-CM

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

Keywords: MDR; BCR-ABL inhibitors; EGFR inhibitors; VEGFR inhibitors; Drug combinations; ABC; ATP binding cassette; ADME-tox; absorption, distribution, metabolism, excretion, toxicity; AKT; v-akt murine thymoma viral oncogene homolog; ALL; acute lymphoblastic leuke

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

Keywords: 3OH-Qi; 3-hydroxy-quinidine; ADME-Tox; absorption, distribution, metabolism, excretion and toxicity; CP100356; N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine; CYP; cytochrome P450; DDI(s); drug

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators

Keywords: DHP; 3D-QSAR; ADME-Tox; CFTR potentiators; GRIND; VolSurf+CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; ADME-Tox, absorption distribution metabolism toxicity; DHP, 1,4-dihydropyridine; QSAR, quantitative structure–activit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

Keywords: Drug Discovery; Pharmaceutical Science; Techniques & Methodshit-to-lead process; HTS; ADME-Tox; hits; leads

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters

Keywords: ABC transporters; ATP-binding cassette transporters; ABCP; placenta-specific ABC protein; ADME-Tox; absorption, distribution, metabolism, and toxicity; AML; acute myeloid leukemia; BCRP; breast cancer resistance protein; FDA; Food and Drug Administration;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه