
Small-molecule modulators of PXR and CAR
Keywords: AF-2, activation function 2; CAR, constitutive androstane receptor; CYP, cytochrome P450; DBD, DNA-binding domain; DDI, drug–drug interactions; DEHP, di(2-ethylhexyl) phthalate; DILI, drug-induced liver injury; DR4, direct repeat separated by 4 nucleotide