Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4+ Th cells cytotoxic by activating both perforin- and FasL-pathways
Keywords: AICD, activation induced cell death; CML, assay cell mediated lysis assay; Con A, Concanavalin A; CTL, cytolytic T lymphocytes; Eomes, eomesodermin; FasL, Fas ligand; PMA, phorbol myristate acetate; RAG, recombination-activation geneCytotoxic T lymphocyte