Insulin rescues ES cell-derived neural progenitor cells from apoptosis by differential regulation of Akt and ERK pathways
Keywords: آکت; ES-NPC; Hypoxia; Insulin; PI3K; Akt; ERK
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Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells
Keywords: آکت; Parathyroid hormone (PTH); PTH-1R; Apoptosis; p85 PI3K; Akt
Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling
Keywords: آکت; Melanin; PI3K; Akt; GSK-3β; MITF
Cardiac aging
Keywords: آکت; Heart; Cardiac function; Drosophila; Mouse; Insulin; PTEN; AKT; TOR; FOXO; Tissue-specific senescence
Alteration in Kinase Activity But Not in Protein Levels of Protein Kinase B and Glycogen Synthase Kinase-3β in Ventral Prefrontal Cortex of Depressed Suicide Victims
Keywords: آکت; Akt; GSK-3α/β; suicide; postmortem prefrontal cortex; major depression disorder
Phenotypic behavior of C2C12 myoblasts upon expression of the dystrophy-related caveolin-3 P104L and TFT mutants
Keywords: آکت; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; HS, horse serum; MHC, myosin heavy chain; NFATC, nuclear factor of activated T-cells; IL-4, Interleukin 4Caveolin 3; Dystrophy; AKT; Follistatin; NFATC2; IL-4; Murf-1; Atrogin
Angiopoietin-1 protects H9c2 cells from H2O2-induced apoptosis through AKT signaling
Keywords: آکت; Angiopoietin-1; Oxidative stress; Myocyte apoptosis; AKT;
Eicosapentaenoic acid inhibits TNF-α-induced Lnk expression in human umbilical vein endothelial cells: involvement of the PI3K/Akt pathway
Keywords: آکت; Eicosapentaenoic acid; Lnk; Endothelial cell; TNF; Akt
A novel method to monitor insulin-stimulated GTP-loading of Rab11a in cardiomyocytes
Keywords: آکت; Rab11a; GLUT4; Akt; GTP-loading;
XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line
Keywords: آکت; XBP-1; Unfolded protein response; ER stress; IGF1; Akt; Anti-apoptosis; Zebrafish;
Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells
Keywords: آکت; PI3K; Akt; Cell cycle; GRP; Bombesin; Neuroblastoma
A component of green tea, (â)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins
Keywords: آکت; Bladder cancer; Akt; EGCG; Apoptosis; Bcl-2;
Selenazoles (selenium compounds) facilitate survival of cultured rat pheochromocytoma PC12 cells after serum-deprivation and stimulate their neuronal differentiation via activation of Akt and mitogen-activated protein kinase, respectively
Keywords: آکت; Akt; Mitogen-activated protein kinase (MAPK) signal cascade; Neurofilament M; PC12 cells; N-Acetyl-l-cysteine (NAC); Buthionine sulfoximine (BSO); Protein tyrosine phosphatases (PTPs); U0126; MAPK kinase (MEK1/2); K252a; TrkA; Pertussis toxin;
Cadmium induces mitogenic signaling in breast cancer cell by an ERα-dependent mechanism
Keywords: آکت; Cadmium; Estrogen receptor; Estradiol; Breast cancer; MAPKs; Akt; PDGFRα; Proto-oncogens
A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer
Keywords: آکت; PTEN; Major vault protein; AKT; EGFR;
Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation
Keywords: آکت; Hypoxia; Akt; Erk; PD98059; LY294002; SDF-1; CXCR4; Transmigration; HL-60
Metabolic consideration of epiphyseal growth: Survival responses in a taxing environment
Keywords: آکت; Chondrocyte; Epiphyseal growth plate; Metabolism; Oxygen; HIF; PHD; mTOR; Akt; AMPK
Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells
Keywords: آکت; Chronic lymphocytic leukemia; B-cell receptor; Syk; ZAP-70; Akt; ERK
EGFR and HER2 Gene Copy Number and Response to First-Line Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer (NSCLC)
Keywords: آکت; epidermal growth factor receptor; HER2; Akt; Chemotherapy; Tyrosine kinase inhibitor; Non-small cell lung cancer
OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis
Keywords: آکت; Angiogenesis; OPC-28326; Ischemia; Akt; eNOS
Signaling pathways of the early differentiation of neural stem cells by neurotrophin-3
Keywords: آکت; Neural stem cells; Neurotrophin-3; Neuronal differentiation; Neurite outgrowth; Akt; ERK; p38
β-Amyloid peptide toxicity in organotypic hippocampal slice culture involves Akt/PKB, GSK-3β, and PTEN
Keywords: آکت; Alzheimer's disease; β-Amyloid; Organotypic culture; Akt; GSK-3β; PTEN
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517
Keywords: آکت; Kinases; PDK-1; AKT; PI 3-kinase; Cancer; Antitumor agent
Hydrogen peroxide attenuates insulin-like growth factor-1 neuroprotective effect, prevented by minocycline
Keywords: آکت; IGF-1; Hydrogen peroxide; Minocycline; Neuron; Akt
GSK-3β regulation in skeletal muscles by adrenaline and insulin: Evidence that PKA and PKB regulate different pools of GSK-3
Keywords: آکت; Glycogen synthase kinase; 8-pCPT-2′-O-Me-cAMP; Akt; cAMP; GSK3; AKAP
Calyculin A stimulates the expression of TNF-α mRNA via phosphorylation of Akt in mouse osteoblastic MC3T3-E1 cells
Keywords: آکت; Akt; Calyculin A; NF-κB; Osteoblasts; Protein phosphatase; TNF-α
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma
Keywords: آکت; Bronchioloalveolar carcinoma; Prognostic factor; NSCLC; Akt; Smoking;
EGFR Genomic Gain and Aberrant Pathway Signaling in Pancreatic Cancer Patients
Keywords: آکت; EGFR; EGF; genomic gain; gene copy number; gene amplification; polysomy; epidermal growth factor receptor; pancreatic cancer; erlotinib; Akt
The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells
Keywords: آکت; Cyclopamine; Hedgehog; Insulin-like growth factor; Akt; p27
Expression of PTEN and Akt phosphorylation in lipopolysaccharide-treated NIH3T3 cells
Keywords: آکت; Akt; Fibroblast; Lipopolysaccharide; Phosphorylation; PTEN;
Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment
Keywords: آکت; Akt; Protein kinase B (PKB); Epidermal growth factor (EGF); Insulin (INS); Serine/threonine phosphorylation
Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus
Keywords: آکت; Estradiol; Rat; Uterus; Phosphatidylinositol-3 kinase; Akt; FOXO1
Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload
Keywords: آکت; Interleukins; Myocardial hypertrophy; Akt; Signal transduction; Mouse; Pressure overload;
Kainate induces AKT, ERK and cdk5/GSK3β pathway deregulation, phosphorylates tau protein in mouse hippocampus
Keywords: آکت; cdk5; GSK3β; Calpain; Akt; tau Phosphorylation
Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells
Keywords: آکت; Ovarian cancer; Genistein; Autophagy; Glucose; Apoptosis; Akt
Effect of demethylasterriquinone b1 in hypertension associated vascular endothelial dysfunction
Keywords: آکت; ACh; acetylcholine; ANOVA; analysis of variance; CMC; carboxy methyl cellulose; DAQ B1; demethylasterriquinone B1; DMSO; dimethyl sulfoxide; DOCA; desoxycortisone acetate; eNOS; endothelial nitric oxide synthase; MABP; mean arterial blood pressure; NBT; n
H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A
Keywords: آکت; 3T3-L1 cells; Adipogenesis; H-89; Protein kinase A; Rho kinase; Phosphoinositide 3-kinase; Akt; Ras; Extracellular signal-regulated kinase 1/2
Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia
Keywords: آکت; Eicosapentaenoic acid; Microglia; NO, PGE2, Proinflammatory cytokines; NF-κB; MAPKs; Akt
Gab2 antisense oligonucleotide blocks rat basophilic leukemic cell functions
Keywords: آکت; Adhesion; Akt; FcεRI; p38 MAPK; RBL-2H3
Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells
Keywords: آکت; Calcification; Apoptosis; Gas6; Axl; Akt; Bcl2
Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation
Keywords: آکت; Rat aorta; Nitric oxide synthase; Potassium channels; Soluble guanylate cyclase; Akt; Vasorelaxation
Nitric oxide induces promyelocytic cell growth arrest and apoptosis through deactivation of Akt pathway
Keywords: آکت; Akt/PKB, protein kinase B; PI, propidium iodide; SNP, sodium nitroprusside; GMP, granulocyte/macrophage progenitorNitric oxide; Granulocyte/macrophage progenitor; Growth arrest; Apoptosis; Akt
Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context
Keywords: آکت; Hsp90; Akt; Geldanamycin; Chaperones
Tissue transglutaminase-mediated chemoresistance in cancer cells
Keywords: آکت; Invasion; Metastasis; Drug resistance; Focal adhesion kinase; β-Integrins; NF-κB; AKT; PTEN; Autophagy; Apoptosis
Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation
Keywords: آکت; FAS; HER2; Diosgenin; Akt; mTOR; JNK
Requirement for Akt-mediated survival in cell transformation by the dbl oncogene
Keywords: آکت; Akt; Apoptosis; Dbl; PI3-kinase; Rho GTPase; Survival; Transformation;
The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation
Keywords: آکت; Wnt3a; Akt; Proliferation; β-catenin; PI3 kinase;
CCN1 protects cardiac myocytes from oxidative stress via β1 integrin–Akt pathway
Keywords: آکت; CCN1; Cardiac myocyte; Oxidative stress; Akt
Induction of stanniocalcin-1 expression in apoptotic human nasopharyngeal cancer cells by p53
Keywords: آکت; GSH; hsp70; Akt; Caspase; Annexin; N-Acetyl cysteine
Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: Mechanisms and consequences
Keywords: آکت; Copper; Zinc; Insulin signaling; Akt; Protein kinase B; FoxO; Protein tyrosine phosphatases; Reactive oxygen species; C. elegans