Keywords: آلوستستیسم; Protein-ligand binding; Thermodynamics; Hierarchical interaction; Cooperativity; Allosterism; Statistical analysis;
مقالات ISI آلوستستیسم (ترجمه نشده)
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Keywords: آلوستستیسم; Allosterism; Molecular recognition; Iodide; Sensors; Colorimetric detection;
Keywords: آلوستستیسم; receptor state affinity constants; functional studies; agonist bias; allosterism; single-receptor behavior;
Keywords: آلوستستیسم; Alcohol; Propofol; Barbiturates; Allosterism; Photolabel; MutagenesisnAChR, nicotinic acetylcholine receptor; ECD, extracellular domain; TMD, transmembrane domain; pLGIC, pentameric ligand-gated ion channel; GABAA, γ-amino-acid type A; Gly, glycine; MWC,
Keywords: آلوستستیسم; Allosterism; Monod; Mechanisms; Theory-nets; Structuralism; Explanation;
Keywords: آلوستستیسم; Allosterism; CavitiesPFK, phosphofructokinase; BsPFK, Bacillus stearothermophilus phosphofructokinase; EcPFK, Escherichia coli phosphofructokinase; Fru-6-P, fructose-6-phosphate; PEP, phospho(enol)pyruvate
Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A
Keywords: آلوستستیسم; GT; glycosyltransferase; HepI; Heptosyltransferase I; Heptose; l-glycero-d-manno-heptose; ADP-Heptose; ADP-l-glycero-d-manno-heptose; LPS; lipopolysaccharide; ODLA; O-deacylated E. coli Kdo2-Lipid A; FDLA; fully-deacylated E. coli Kdo2-Lipid A; LPS; Lipop
Characterisation of endogenous A2A and A2B receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor⢠biosensor: Evidence for an allosteric mechanism of action for the A2B-selective antagonist PSB 603
Keywords: آلوستستیسم; A2AAR; A2A adenosine receptor; A2BAR; A2B adenosine receptor; BAY 60-6583; (2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; HEK293G; Human Embryonic Kidney 293 cell line stably expressing the GloSensor⢠biosensor; D
A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines
Keywords: آلوستستیسم; Alprenolol (Pubchem CID: 2119); CGP 12177 (Pubchem CID: 2687); CGP 20712A (Pubchem CID: 2685); Cimaterol (Pubchem CID: 2755); Furimazine (Pubchem CID: 219083); Hoechst 33342 (Pubchem CID: 1464); IBMX (Pubchem CID: 3758); ICI 118551 (Pubchem CID: 5484725);
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators
Keywords: آلوستستیسم; Sphingosine 1-phosphate; B-alkyl Suzuki cross-coupling; FTY720; Epoxide opening; Allosterism;
Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1
Keywords: آلوستستیسم; FFA1; GLP-1; Allosterism; Type 2 diabetes
Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin
Keywords: آلوستستیسم; Allosterism; Alzheimer; GSK-3 inhibition; Molecular dynamics; Drug designATP, adenosine triphosphate; CK2, casein kinase 2; CDK1, cyclin-dependent kinase 1; CDK5, cyclin-dependent kinase 5; ELISA, enzyme-linked immunosorbent assay; EDTA, ethylene-diamine-
AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases
Keywords: آلوستستیسم; AGC kinase; PIF-pocket; Allosterism; PDK1; PRK; atypical PKC
A new approach for studying GPCR dimers: Drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo
Keywords: آلوستستیسم; GPCR; Homodimer; Heterodimers; 5-HT7; 5-HT2A; Allosterism
Photochemically relevant DNA-based molecular systems enabling chemical and signal transductions and their analytical applications
Keywords: آلوستستیسم; DNA; Oligonucleotide; Allosterism; Functional DNA; Ribozyme; DNAzyme; Aptamer; Metal base pair; Assembly; DNA machine; DNA device; Bioorthogonal reaction; Staudinger reaction; Click chemistry; Fluorescence; Conductivity; Photochemical ligation
When simple agonism is not enough: Emerging modalities of GPCR ligands
Keywords: آلوستستیسم; G protein-coupled receptor; Functional selectivity; Allosterism; Ago-allosterism; Dualsteric ligand; Super-agonism;
Drug discovery and the human kinome: Recent trends
Keywords: آلوستستیسم; Allosterism; Protein–protein interactions; Kinase translocation; Growth factor agonists/antagonistsATP, adenosine triphosphate; AKT, v-akt murine thymoma viral oncogene homolog; BRAF, v-raf murine sarcoma viral oncogene homolog B1; BDNF, brain-derived neu
Bioinformatics and mathematical modelling in the study of receptor–receptor interactions and receptor oligomerization : Focus on adenosine receptors
Keywords: آلوستستیسم; Bioinformatic; G protein-coupled receptor; Oligomerization; Receptor–receptor interaction; Receptor Mosaic; Allosterism; Adenosine receptor
Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative
Keywords: آلوستستیسم; M2 muscarinic receptor; McN-A-343; Allosterism; Competitive inhibition; Irreversible binding;
Enhancer and competitive allosteric modulation model for G-protein-coupled receptors
Keywords: آلوستستیسم; Ligand–receptor interactions; Allosterism; Drug screening; PD81723
Receptor-receptor interactions: A novel concept in brain integration
Keywords: آلوستستیسم; AI; Aggregation Index; AFM; Atomic Force Microscopy; CPs; Check-Points; CHO; Chinese Hamster Ovary; DOR; Delta opioid receptors; DI; Disorder Index; DA; dopamine; GPCRs; G-protein coupled receptors; Hcy; homocysteine; KOR; kappa opioid receptors; LTD; lon
A preliminary step toward molecular spring driven by cooperative guest binding
Keywords: آلوستستیسم; Porphyrinoids; Allosterism; Molecular recognition; Molecular machinery;
Membrane signalling complexes: Implications for development of functionally selective ligands modulating heptahelical receptor signalling
Keywords: آلوستستیسم; Stimulus trafficking; Allosterism; Signalling complex; Multimeric arrays; Multiple active conformations; BRET; Opioid; GPCR
N,N′-Bis(benzamido)thioureas as anion receptors
Keywords: آلوستستیسم; Amidothiourea; Anion receptor; Organocatalyst; Hydrogen bonding; Charge transfer; Allosterism
Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4
Keywords: آلوستستیسم; Cytochrome P4503A4; Drug metabolism; Allosterism; Homotropic effectors; Nile Red; Solvatochromism;
A comparison of substrate dynamics in human CYP2E1 and CYP2A6
Keywords: آلوستستیسم; CYP2E1; CYP2A6; Isotope effect; Cooperativity; Allosterism; Dynamics; P450; kH/kD; Xylene
Energetics of heterotropic cooperativity between α-naphthoflavone and testosterone binding to CYP3A4
Keywords: آلوستستیسم; Binding; Thermodynamics; CYP; Allosterism; Drug-interactions; CYP3A4; EPR; Cooperativity plot; Testosterone; α-Naphthoflavone
Structural studies of thermal- and light- induced transitions in iron(II) spin-crossover complexes
Keywords: آلوستستیسم; Spin-crossover; Spin transition; Molecular magnetism; Crystal structure; LIESST; Variable temperature diffraction studies; Iron(II) complexes; Coordination polymers; Polymorphism; Allosterism; Croisement de spin; Transition de spin; Magnétisme moléculai
Spectroscopic characterization of the EF-hand domain of phospholipase C δ1: Identification of a lipid interacting domain
Keywords: آلوستستیسم; Phospholipase C; EF-hand domain; Fatty acids; Fluorescence spectroscopy; Allosterism; FRET; Calcium binding; Circular dichroism; Arachidonic acid; Hydrophobic interaction;