Keywords: ترتیب ناهنجاری کانال پانکراس بیوتیار; GBC; gallbladder cancer; GSD; gallstone disease; PTGS2 (COX-2); prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); AAPBD; anomalous arrangement of the pancreaticobiliary duct; PSC; primary sclerosing cholangitis; LXRs;