دانلود مقالات ISI درباره APAP، استامینوفن + ترجمه فارسی

Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats

Keywords: APAP، استامینوفن; Acetaminophen; Emodin; Lipid peroxidation; Reduced glutathione; Liver marker enzymesATPase, adenosine triphosphatase; APAP, acetaminophen; ACPase, acid phosphatase; ALT, alanine aminotransferae; SALP, serum alkaline phosphatase; ALPase, alkaline phosphata

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

Keywords: APAP، استامینوفن; Bile acids; Bilirubin; Statins; Fibrates; Glitazones; Primary biliary cirrhosis; Primary sclerosing cholangitisAhR, aryl hydrocarbon receptor; ASBT/Asbt (SLC10A2/Slc10a2), apical sodium-dependent bile acid transporter; APAP, acetaminophen; BSEP/Bsep (ABCB

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2010 سفارش ترجمه

Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection

Keywords: APAP، استامینوفن; AA, arjunolic acid; ALT, alanine transaminase; APAP, acetaminophen; DCF-DA, 2′,7′-dichlorofluorescein diacetate; FACS, fluorescence-activated cell sorting; GSH, glutathione; JNK, c-Jun-NH2-terminal protein kinase; LDH, lactate dehydrogenase; MPT, mitochon

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2010 سفارش ترجمه

Co-medications That Modulate Liver Injury and Repair Influence Clinical Outcome of Acetaminophen-Associated Liver Injury

Keywords: APAP، استامینوفن; ACEI, angiotensin-converting enzyme inhibitor; AERS, Adverse Event Reporting System; APAP, acetaminophen; ATC, Anatomical Therapeutic Chemical; ATIIA, angiotensin II receptor antagonist; FDA, Food and Drug Administration; HGF, hepatocyte growth factor; NS

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress

Keywords: APAP، استامینوفن; AhR, aryl hydrocarbon receptor; APAP, acetaminophen; DMA, dimethylarsinic acid; ARNT, aryl hydrocarbon nuclear translocator; ASK-1, apoptosis signal-regulating kinase 1; BAP, benzo[a]pyrene; CAT, catalese; CYP, cytochromes P450; EGF, epidermal growth fact

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Dermal penetration and metabolism of p-aminophenol and p-phenylenediamine: Application of the EpiDerm™ human reconstructed epidermis model

Keywords: APAP، استامینوفن; APAP, acetaminophen; CYP, cytochrome P450; DAPPD, N,N′-diacetyl-p-phenylenediamine; d4-PAP, p-aminophenol-ring deuterium labelled; d4-PPD, p-phenylenediamine sulphate-ring deuterium labelled; DMSO, dimethyl sulphoxide; DPBS, Dulbecco's phosphate buffered

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

Keywords: APAP، استامینوفن; APAP, acetaminophen; Cmax, average plasma maximum drug concentration; CM-H2DCFDA, 5-(and-6)-chloromethyl-2′7′-dichlorodihydrofluorescein diacetate acetyl ester; TMRM, tetramethyl rhodamine ester; DILI, drug-induced liver injury; DRAQ5, 1,5-bis{[2-(di-meth

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

Keywords: APAP، استامینوفن; 1,24,25(OH)2D3, 1,24,25-trihydroxyvitamin D3; 1,25(OH)2D3, 1,25-dihydroxyvitamin D3; 25(OH)D3, 25-hydroxyvitamin D3; ABC, ATP-binding cassette; AhR, aryl hydrocarbon receptor; Aldh, aldehyde dehydrogenase; APAP, acetaminophen; AR, androgen receptor; ASC,

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2009 سفارش ترجمه

Effects of tomato extract on oxidative stress induced toxicity in different organs of rats

Keywords: APAP، استامینوفن; ADN, amiodarone; APAP, acetaminophen; CsA, cyclosporine A; GSH, reduced glutathione; LDL, low-density lipoprotein; MDA, malondialdehyde; NAPQI, N-acetyl-p-benzoquinoneimine; ROS, reactive oxygen speciesAcetaminophen; Amiodarone; Cyclosporine A; GSH; Tomat

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats

Keywords: APAP، استامینوفن; APAP, acetaminophen; GENT, gentamicin; i.p., intraperitoneal route; NS, normal saline; PA, aqueous leaf and seed extract of Phyllanthus amarus; p.o., per osPhyllanthus amarus; Leaf and seed aqueous extract; Gentamicin- and acetaminophen- induced nephrotox

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

Keywords: APAP، استامینوفن; APAP, acetaminophen; NAPQI, N-acetylbenzoquinoneimine; MTT, 3-(4,5-dimethylthiazol 2-yl)-2,5 diphenyltetrazolium bromide; CYP, cytochrome P450; Mrp, multidrug resistance-associated proteinAcetaminophen toxicity; Hepatocyte; Species difference

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models

Keywords: APAP، استامینوفن; APAP, acetaminophen; COX, cyclooxygenase; LPS, lipopolysaccharide; NMDA, N-methyl-d-aspartate; NSAID, non-steroidal anti-inflammatory drug; SP, substance P; s.c., subcutaneously; i.t., intrathecal; i.c.v., intracerebroventricularLipopolysaccharide; Acetam

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Role of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver

Keywords: APAP، استامینوفن; ALS, amyotrophic lateral sclerosis; APAP, acetaminophen; BSA, bovine serum albumin; LPS, lipopolysaccharide; PBS, phosphate-buffered saline; SOD1, copper,zinc-superoxide dismutase; SOD1−/−, SOD1 knockout mice; WT, wild type.SOD1; Protein nitration; Acetam

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine

Keywords: APAP، استامینوفن; A77–1726, teriflunomide, N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide; APAP, acetaminophen; DDTC, sodium diethyldithiocarbamate trihydrate; DMSO, dimethyl sulfoxide; ESI +ve, electrospray positive ionization mode; ESI −ve, electrospray negative

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

Keywords: APAP، استامینوفن; APAP, acetaminophen; ALT, alanine aminotransferase; AREs, antioxidant response elements; Abcc, ATP-binding cassette, subfamily c; bDNA, branched DNA signal amplification; DAPI, 4′,6-diamidino-2-phenylindole; Gclc, glutamate cysteine ligase catalytic; Gclm

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

Keywords: APAP، استامینوفن; APAP, acetaminophen; ASK1, apoptosis signal-regulating kinase 1; GSH, glutathione; IL, interleukin; JNK, c-jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MAPKKK, mitogen-activated protein kinase kinase kinase; MKK, mitogen-activated protei

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor

Keywords: APAP، استامینوفن; ALV, alvimopan; APAP, acetaminophen; BM, bowel movement; BW373U86, (±)-4-((α-R⁎)-α-((2S⁎, 5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethyl-benzamide; CNS, central nervous system; CRT, colorectal transit; DADLE, D-Ala2, N-MePhe4, Gly5-o

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2008 سفارش ترجمه

Protective effect of silymarin on oxidative stress in rat brain

Keywords: APAP، استامینوفن; Oxidative stress; Glutathione; Micromethod; Silymarin; APAP; BrainAA, ascorbic acid; APAP, acetaminophen; GSH, reduced glutathione; GSSG, oxidized glutathione; LP, lipid peroxidation; MDA, malondialdehyde; ROS, reactive oxygen species; SOD, superoxide dis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model

Keywords: APAP، استامینوفن; APAP, acetaminophen; CD68, macrosialin; COX, cyclooxygenase; CySSG, L-cysteine-glutathione mixed sulfide; DSS, dextran sodium sulfate; ELISA, enzyme-linked immunosorbent assay; GSH, glutathione; GSSG, oxidized glutathione; HPLC, high-performance liquid ch

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: Role of male sex hormone

Keywords: APAP، استامینوفن; APAP, acetaminophen; CYP, cytochrome P450; GSH, glutathione; NAPQI, N-acetyl-p-benzoquinoneimine; HAI, hepatitis activity index; ALT, alanine aminotransferase; SDH, sorbitol dehydrogenase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, cre

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Effect of acetaminophen administration to rats chronically exposed to depleted uranium

Keywords: APAP، استامینوفن; ABC, ATP binding cassette; CYP, cytochrome P450; ALT, alanine amino-transferase; APAP, acetaminophen; AST, aspartate amino-transferase; DU, depleted uranium; GST, glutathione-S-transferase; HPRT, hypoxanthine–guanine phosphoribosyltransferase; MDR, multid

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Mild Hypothermia Attenuates Liver Injury and Improves Survival in Mice With Acetaminophen Toxicity

Keywords: APAP، استامینوفن; ALF, acute liver failure; APAP, acetaminophen; BrdU, 5-bromo-2-deoxyuridine; HT, hypothermic; NAPQI, N-acetyl-p-benzoquinone imine; NT, normothermic; PARP, poly(ADP-ribose) polymerase; Sal, saline; TdT, terminal deoxynucleotidyl transferase; TUNEL, termin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

Keywords: APAP، استامینوفن; A77 1726, teriflunomide, N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide; ANT, adenosine nucleotide translocator; APAP, acetaminophen; CsA, cyclosporin A; DMSO, dimethyl sulfoxide; ΔΨm, mitochondrial inner transmembrane potential; JNK, c-Jun NH2-t

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

An experimental design for the controlled modulation of intracellular GSH levels in cultured hepatocytes

Keywords: APAP، استامینوفن; APAP, acetaminophen; ASAT, aspartate aminotransferase; BSO, l-buthionine-S-sulfoximine; CYP, cytochrome P450; DEM, diethylmaleate; GCS, γ–glutamylcysteine synthetase; GSH, reduced glutathione; GSH-EE, glutathione monoethylester; GST, glutathione-S-transfe

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Modeling inflammation–drug interactions in vitro: A rat Kupffer cell-hepatocyte coculture system

Keywords: APAP، استامینوفن; IL-10, interleukin 10; TNF-α, tumor necrosis factor; PGE2, prostaglandin E2; Gro/KC, growth-related oncogene KC; IFN-γ, interferon gamma; MCP-1, monocyte chemoattractant protein 1; LPS, lipopolysaccharide; APAP, acetaminophen; CPZ, chlorpromazine; AlOH, a

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

c-Jun N-Terminal Kinase Plays a Major Role in Murine Acetaminophen Hepatotoxicity

Keywords: APAP، استامینوفن; APAP, acetaminophen; ASO, antisense oligonucleotide; Cl2MBP, dichloromethylene-bisphosphonate; Con A, concanavalin A; COX IV, cytochrome oxidase IV; CYP, cytochrome p-450; DMSO, dimethyl sulfoxide; JNK, c-jun N-terminal kinase; LPS, lipopolysaccharide; NA

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

Monitoring drug–protein interaction

Keywords: APAP، استامینوفن; ALT, alanine aminotransferas; APAP, acetaminophen; COX, cyclooxygenase; CYP, cytochrome P450; 2,6-DMA, 2,6-dimethylaniline; DMXAA, 5,6-dimethylxanthenone-4-acetic acid; ELISA, enzyme-linked immunosorbent assay; GC-MS, gas chromatography mass spectrometry;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2006 سفارش ترجمه