
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells
Keywords: Arsenite; Mitochondria; NADPH Oxidase; Superoxide; ER Stress; Autophagy; ApoptosisAnt, antimycin A; Apo, apocynin; CHOP, GADD153/C/EBP homologous protein; Cf, caffeine; CsA, cyclosporin A; DHR, Dihydrorhodamine 123; DPI, diphenyleneiodonium; ER, endoplasm