دانلود مقالات ISI درباره APP، پروتئین پیش ماده آمیلوئید + ترجمه فارسی

Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses

Keywords: APP، پروتئین پیش ماده آمیلوئید; amyloid precursor protein; synaptic transmission; neuromuscular junction; calcium channels; asynchronous releaseAβ, β-amyloid peptide; AChR, acetylcholine receptor; AD, Alzheimer’s disease; APLP2, APP-like protein 2; APP, amyloid precursor protein; α-BTX,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Phospholipase D1 is associated with amyloid precursor protein in Alzheimer's disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; FAD, familial Alzheimer's disease; APP, amyloid precursor protein; Aβ, β-amyloid; NFT, neurofibrillary tangles; PLD, phospholipase D; CEM, caveolin-enriched membrane; ARF, ADP-ribosylation factor; PC, phosphatidylcholine; PA, phos

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β-peptide; ABTS, 2,2′-azino-di-3-ethylbenzthiazoline sulphonate; AD, Alzheimer's disease; APP, amyloid precursor protein; CM-H2,DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; ECL, enhanced chemiluminescence; FAD, familial Alzheimer's disea

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Genomic analysis of response to traumatic brain injury in a mouse model of Alzheimer's disease (APPsw)

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, beta-amyloid peptide; AD, Alzheimer's disease; APP, amyloid precursor protein; APPsw, Alzheimer's mouse model with the “Swedish” mutation; CCI, controlled cortical impact; IPA, Ingenuity Pathway Analysis; TBI, traumatic brain injuryTraumatic brain inj

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Structural Studies of the Alzheimer’s Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions

Keywords: APP، پروتئین پیش ماده آمیلوئید; APP, Amyloid precursor protein; APS, Advanced Photon Source; BACE, β-site APP cleaving enzyme; CuBD, copper binding domain of APP; EPR, electron paramagnetic resonance; EXAFS, extended X-ray absorption fine structure; GFD, growth factor domain of APP; r.m

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer’s transgenic mice

Keywords: APP، پروتئین پیش ماده آمیلوئید; DHA; EPA; β-amyloid; memoryAβ, β-amyloid; AD, Alzheimer’s disease; ANOVA, analysis of variance; APP, amyloid precursor protein; DEA, diethylamine; DFA, discriminant function analysis; DHA, docosahexaenoic acid; ELISA, sandwich enzyme-linked immunosorbent

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature

Keywords: APP، پروتئین پیش ماده آمیلوئید; ACh, acetylcholine; AChE, acetylcholinesterase; APP, amyloid precursor protein; BuChE, butyrylcholinesterase; ChAT, choline acetyltransferase; GABA, gamma aminobutyric acid; NMDA, N-methyl-d-aspartate; PKC, protein kinase C; TCM, traditional Chinese medic

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2007 سفارش ترجمه

Permanent, bilateral common carotid artery occlusion in the rat: A model for chronic cerebral hypoperfusion-related neurodegenerative diseases

Keywords: APP، پروتئین پیش ماده آمیلوئید; α7NicR, α7-nicotinic acetylcholine receptor; 2VO, permanent, bilateral common carotid artery occlusion, two-vessel occlusion; AD, Alzheimer's disease; APP, amyloid precursor protein; BBB, blood–brain barrier; BDNF, brain-derived neurotrophic factor; CBF,

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2007 سفارش ترجمه

Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

Keywords: APP، پروتئین پیش ماده آمیلوئید; 3-NT, 3-nitrotyrosine; 8-OHdG, 8-hydroxy-2-deoxyguanine; 8-OHG, 8-hydroxyguanine; Aβ, amyloid β-peptide; AD, Alzheimer disease; APP, amyloid precursor protein; CAII, carbonic anhydrase II; CK BB, creatine kinase BB isoform; CSF, cerebrospinal fluid; DHAP,

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2007 سفارش ترجمه

The role of amyloid β peptide 42 in Alzheimer's disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β peptide; AβX, amyloid β peptide of the length specified by X, starting at residue 1; AChEI, acetylcholinesterase inhibitor; AD, Alzheimer's disease; AICD, amyloid precursor protein intracellular domain; APP, amyloid precursor protein; ATP, a

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2007 سفارش ترجمه

Therapeutic RNA interference for neurodegenerative diseases: From promise to progress

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer’s disease; APP, amyloid precursor protein; BACE1, β-site APP cleaving enzyme; dsRNA, double-stranded RNA; FALS, familial amyotrophic lateral sclerosis; HD, Huntington’s disease; IR, interferon response; IRG, interferon-responsive genes; miRN

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2007 سفارش ترجمه

Stress and ageing interactions: A paradox in the context of shared etiological and physiopathological processes

Keywords: APP، پروتئین پیش ماده آمیلوئید; ACTH, adrenocorticotropic hormone; ApoE, apolipoprotein E; APP, amyloid precursor protein; Bcl-2, B cell lymphoma protein-2; BDNF, brain-derived nerve growth factor; BH, Bcl-2 homology; BN, Brown Norway; C. elegans, Caenorhabditis elegans; COX-2, cyclooxy

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2007 سفارش ترجمه

Oxidative stress: A bridge between Down's syndrome and Alzheimer's disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; ADH, alcohol dehydrogenase; AGE, advanced glycation end-product; ALC, acetyl-l-carnitine; APP, amyloid precursor protein; AP-1, activator protein-1; Aβ, amyloid beta protein; BACE, β-site amyloid precursor protein cleaving enzyme

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2007 سفارش ترجمه

Diethylamine extraction of proteins and peptides isolated with a mono-phasic solution of phenol and guanidine isothiocyanate

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β peptide; APP, amyloid precursor protein; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio] propanesulfonate; DC, deoxycholic acid; DEA, diethylamine; SDS, sodium dodecyl sulfate.Protein extraction; Protein expression analysis; Alzheimer's disea

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Genetic study of Sardinian patients with Alzheimer's disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β; AD, Alzheimer's disease; APP, amyloid precursor protein; APOE, apolipoprotein E; PSEN1, presenilin 1; PSEN2, presenilin 2; NCSTN, nicastrin; PEN2, presenilin enhancer-2; EOAD, early onset Alzheimer's disease; LOAD, late onset Alzheimer's di

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative α-secretases, ADAM10 and TACE, without altering their mRNA levels

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; Aβ, amyloid-β-peptide; ADAM10, a disintegrin and metalloproteinase 10; ADAM17, a disintegrin and metalloproteinase 17; APP, amyloid precursor protein; BACE1, β-amyloid converting enzyme; CH, chronic hypoxia; sAPPα, soluble α-secre

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β-peptide; APP, amyloid precursor protein; β-CTF, β-C-terminal fragment of APP; DMEM, Dulbecco's modified eagle medium; GnRH, gonadotropin releasing hormone; HRP, horseradish peroxidase; pGlu, pyroglutamic acid; QC, glutaminyl cyclase; SDS-PAG

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

PEGylated phospholipid nanomicelles interact with β-amyloid(1–42) and mitigate its β-sheet formation, aggregation and neurotoxicity in vitro

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; APP, amyloid precursor protein; Aβ, beta-amyloid; CD, circular dichroism; CMC, critical micellar concentration; CR, Congo red; DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000); EM,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Quantitative analysis of amyloid plaques in a mouse model of Alzheimer’s disease by phase-contrast X-ray computed tomography

Keywords: APP، پروتئین پیش ماده آمیلوئید; β-amyloid; physical density; imaging; dystrophic neuritic; PSAPP miceAβ, β-amyloid; AD, Alzheimer’s disease; APP, amyloid precursor protein; CT, computed tomography; ELISA, enzyme-linked immunosorbent assay; HD, high-density; HEPES, 2-[4-(2-hydroxyethyl)-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β; APP, Amyloid Precursor Protein; AD, Alzheimer's disease; ApoE, Apolipoprotein E; CSF, cerebrospinal fluid; DRP-2, dihydropyrimidinase-related protein-2; 2DE, two-dimensional electrophoresis; MS, mass spectrometry; MS/MS, tandem mass spectro

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis

Keywords: APP، پروتئین پیش ماده آمیلوئید; APP, amyloid precursor protein; ERM, ezrin/radixin/moesin; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; MBP, myelin basic protein; NF, neurofilament; PLP, proteolipid protein.Fasudil; Rho-kinase; Multiple sclerosis; Experimental autoimmune encephalomye

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Effects of statins beyond lipid lowering: Potential for clinical benefits

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, beta-amyloid; AD, Alzheimer's disease; AMD, age-related macular degeneration; APP, amyloid precursor protein; BNP, B-type (brain) natriuretic peptide; CGN, chronic glomerulonephritis; CHD, coronary heart disease; CHF, congestive (chronic) heart failur

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology

Keywords: APP، پروتئین پیش ماده آمیلوئید; Amyloid β; Alzheimer's disease; Cell cycle; Microglia; Neuroinflammation; RegenerationAβ, amyloid β; ACT, α1-antichymotrypsin; AD, Alzheimer's disease; ApoE, apolipoprotein E; APP, amyloid precursor protein; CNS, central nervous system; COX-2, cyclooxygen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer’s disease brain

Keywords: APP، پروتئین پیش ماده آمیلوئید; zinc transporters; ZnT; Alzheimer’s disease; AD; mild cognitive impairment; MCIAD, Alzheimer’s disease; APP, amyloid precursor protein; Aβ, amyloid β-peptide; CER, cerebellum; EAD, early Alzheimer’s disease; HPG, hippocampus/parahippocampal gyrus; INAA, i

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Injury to axons and oligodendrocytes following endothelin-1-induced middle cerebral artery occlusion in conscious rats

Keywords: APP، پروتئین پیش ماده آمیلوئید; APP, amyloid precursor protein; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; ET-1, endothelin-1; MCAO, middle cerebral artery occlusion; NMDA, N-methyl-d-aspartate; PBS, phosphate-buffered saline; TTC, 2,3,5-triphenyltetrazolium chloride;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Differentially expressed cortical genes contribute to perivascular deposition in transgenic mice with inducible neuron-specific expression of TGF-β1

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; A2m, α-2-macroglobulin; ApoE, apolipoprotein E; APP, amyloid precursor protein; CamKIIα, calcium/calmodulin kinase IIα; Cldn5, claudin 5; Ctla2, cytotoxic T lymphocyte-associated protein 2 alpha; Ctss, cathepsin S; CSF, cerebrospi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Amyloid β and neuromelanin—Toxic or protective molecules?: The cellular context makes the difference

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer disease; Aβ, amyloid beta; APP, amyloid precursor protein; NM, neuromelanin; IL-6, interleukin-6; NO, nitric oxide; PD, Parkinson's disease; SN, substantia nigra; TNF-α, tumor necrosis factor-α; VMAT2, vesicular monoamine transporter 2Amyloi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Amyloid β peptide (25–35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β; AD, Alzheimer's disease; APP, amyloid precursor protein; COX, cyclooxygenase; NSAIDs, non-steroidal anti-inflammatory drugs; PG, prostaglandin; PKC, protein kinase CAlzheimer's disease; Aβ25–35; Astroglia; CNS; Non-steroidal anti-inflammato

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann–Pick disease type C and Alzheimer's disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, β-amyloid; AD, Alzheimer's disease; APP, amyloid precursor protein; CHO, Chinese hamster ovary; CoA, coenzyme A; ER, endoplasmic reticulum; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

Keywords: APP، پروتئین پیش ماده آمیلوئید; Alzheimer's disease; Apolipoprotein E; Cholesterol; Rat hippocampal neurons; Rat hippocampal astrocytesapoA, apolipoprotein A; apoE, apolipoprotein E; APP, amyloid precursor protein; dapi, bisbenzimide dye Hoechst 33342; FCS, fetal calf serum; GFAP, glial

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Structural Differences in Aβ Amyloid Protofibrils and Fibrils Mapped by Hydrogen Exchange – Mass Spectrometry with On-line Proteolytic Fragmentation

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; APP, amyloid precursor protein; HX-MS, hydrogen-deuterium exchange-mass spectrometry; D, deuterium; CLC, calmidazolium chloride; ESI, electrospray ionization; LCamyloid fibrils; protofibrils; hydrogen-deuterium exchange; mass spec

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Trace amounts of copper induce neurotoxicity in the cholesterol-fed mice through apoptosis

Keywords: APP، پروتئین پیش ماده آمیلوئید; Copper; Cholesterol; Neurotoxicity; ApoptosisAβ, amyloid-β peptide; APP, amyloid precursor protein; CuBD, copper binding domain; Cu, Zn,-SOD, Cu–Zn superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; TUNEL, terminal deoxynucleotidyl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Altered β-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer’s disease brain

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, amyloid β-peptide; AD, Alzheimer’s disease; APP, amyloid precursor protein; BACE, β-site APP-cleaving enzyme; DNP, 2,4-dinitrophenyl; EDTA, ethylene-diamine-tetra-acetic acid; HEK293, human embryonic kidney 293; Km, Michaelis constant; MCA, 7-methoxyc

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

The spirostenol (22R, 25R)-20α-spirost-5-en-3β-yl hexanoate blocks mitochondrial uptake of Aβ in neuronal cells and prevents Aβ-induced impairment of mitochondrial function

Keywords: APP، پروتئین پیش ماده آمیلوئید; AChEI, acetylcholinesterase inhibitor; Aβ, β-amyloid peptide; ADDLs, amyloid-derived diffusible ligands; ANT, adenine nucleotide translocase; APP, amyloid precursor protein; CCCP, carbonyl cyanide 3-chlorophenylhydrazone; FCCP, carbonyl cyanide p-trifluor

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Transgenic mice over-expressing human β-amyloid have functional nicotinic alpha 7 receptors

Keywords: APP، پروتئین پیش ماده آمیلوئید; Alzheimer’s disease; transgenic; hippocampus; memory; ion channel; electrophysiologyACh, acetylcholine; aCSF, artificial cerebrospinal fluid; AD, Alzheimer’s disease; APP, amyloid precursor protein; Aβ, amyloid β peptide; MLA, methyllycaconitine citrate;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; apoE, apolipoprotein E; apoER2, apolipoprotein E type 2 receptors; APP, amyloid precursor protein; CDK-5, cyclin-dependent protein kinase-5; CHO, Chinese hamster ovary cells; CNR1, cadherin-related neuronal receptor protein; CpG,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3β and a caspase-9-dependent apoptosis in cerebellar granule neurons

Keywords: APP، پروتئین پیش ماده آمیلوئید; 2-APB, 2-aminoethoxydiphenyl borate; Aβ, amyloid β; APP, amyloid precursor protein; BA, brefeldin A; CGN, cerebellar granule neuron; DAPI, 4,6-diamindino-2-phenylindole; DMEM, Dulbecco's modified Eagles medium; ER, endoplasmic reticulum; FITC, fluorescein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Amyloid-β Peptide Disruption of Lipid Membranes and the Effect of Metal Ions

Keywords: APP، پروتئین پیش ماده آمیلوئید; amyloid Aβ; peptide–Lipid interactions; membranes; solid-state NMR; structureAβ, β-amyloid peptide; AD, Alzheimer's disease; APP, amyloid precursor protein; CD, circular dichroism spectroscopy; CSA, chemical shift anisotropy; CuGly2, copper glycine; DPH,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; FAD, familial form of Alzheimer's disease; Aβ, amyloid β-peptide; APP, amyloid precursor protein; PS, presenilin; ER, endoplasmic reticulum; IP3, inositol 1,4,5-trisphosphate; Bk, bradykinin; Hist, histamine; Cch, carbachol; Tg, t

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Amino-terminal Domain Stability Mediates Apolipoprotein E Aggregation into Neurotoxic Fibrils

Keywords: APP، پروتئین پیش ماده آمیلوئید; AB, 100 mM NH4HCO3 (pH 7.8); apo, apolipoprotein; AD, Alzheimer's disease; APP, amyloid precursor protein; CSF, cerebrospinal fluid; GFAP, glial fibrillary acidic protein; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PBS, 135 mM NaCl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer’s disease; APP, amyloid precursor protein; BDNF, brain-derived neurotrophic factor; CRE, cyclic AMP response element; CREB, cyclic AMP response element binding protein; CBP, CREB-binding protein; DAPI, 4′,6-diamidino-2-phenylindole; FBS, fet

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

High-resolution Atomic Force Microscopy of Soluble Aβ42 Oligomers

Keywords: APP، پروتئین پیش ماده آمیلوئید; Alzheimer's disease; amyloid beta; soluble oligomer; protofibrils; atomic force microscopyAFM, atomic force microscopy; APP, amyloid precursor protein; EM, electron microscopy; FTIR, Fourier transform infrared; MW, molecular weight; MPL, mass-per-length;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer’s disease in a sex-dimorphic pattern

Keywords: APP، پروتئین پیش ماده آمیلوئید; spatial working memory; recognition memory; celecoxib; APPswe-PS1dE9 mice; three-trial Y maze; sex differencesAD, Alzheimer’s disease; APP, amyloid precursor protein; APPswe, amyloid precursor protein with Swedish mutation; COX-2, cycloxygenase-2; FAD, fa

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

The cell cycle as a therapeutic target for Alzheimer's disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; APP, amyloid precursor protein; APP-BP1, APP binding protein 1; cdk, cyclin-dependent kinase; CSN, Cop9 signalosome; FAD, familial AD; JNK3, c-Jun N-terminal kinase 3; NSAID, nonsteroidal anti-inflammatory drug; PAK3, p21-activate

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه

High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain

Keywords: APP، پروتئین پیش ماده آمیلوئید; mass spectrometry; pathological aging; pyroglutamate; ultrastructure; laser dissection microscopy; Alzheimer’s diseaseAD, Alzheimer’s disease; Aβ, amyloid beta peptide; APP, amyloid precursor protein; BSA, bovine serum albumin; CAA, cerebral amyloid angio

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

Keywords: APP، پروتئین پیش ماده آمیلوئید; analytical ultracentrifugation; modeling; signal transduction; small-angle X-ray scattering; structural domainsAD, Alzheimer's disease; APP, amyloid precursor protein; sAPPα, soluble extracellular domain of the amyloid precursor protein released by α-secr

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2006 سفارش ترجمه

A Molecular Dynamics Approach to the Structural Characterization of Amyloid Aggregation

Keywords: APP، پروتئین پیش ماده آمیلوئید; amyloid; Alzhemer's disease; prion; protein aggregation; site-directed mutagenesisMD, molecular dynamics; APP, amyloid precursor protein; REMD, replica exchange MD; ThT, thioflavin T; EPR, electron paramagnetic resonance; SS, secondary structure; hIAPP, h

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2006 سفارش ترجمه

Transcriptional and translational regulation of BACE1 expression—Implications for Alzheimer's disease

Keywords: APP، پروتئین پیش ماده آمیلوئید; Aβ, β-amyloid peptide; AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; BACE, APP-cleaving enzyme; ChAT, choline acetyltransferase; MEF, mouse embryonic fibroblasts; NF-κB, nuclear factor kappa B; NSAIDs, n

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2006 سفارش ترجمه

RACK1 has the nerve to act: Structure meets function in the nervous system

Keywords: APP، پروتئین پیش ماده آمیلوئید; AC, adenylyl cyclase; AChE, acetylcholinesterase; AChE-R, “the read-through” variant of AChE; AD, Alzheimer's disease; Agtrap, angiotensin II receptor-associated protein; AKAP, A-kinase anchoring proteins; APP, amyloid precursor protein; BDNF, brain-deriv

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2006 سفارش ترجمه

Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal models

Keywords: APP، پروتئین پیش ماده آمیلوئید; AD, Alzheimer's disease; Aβ, beta amyloid; ApoE, apolipoprotein E; APP, amyloid precursor protein; cDNA, complementary DNA; FAD, familial Alzheimer's disease; PS1, presenilin 1; PS2, presenilin 2; SAD, sporadic Alzheimer's disease; NFTs, neurofibrillary t

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2006 سفارش ترجمه