Keywords: منطقه تحت منحنی غلظت-زمان; AL; alantolactone; AL-GSH; glutathione conjugate of alantolactone; AL-Cys; cysteine conjugate of alantolactone; AUC; area under the concentration-time curve; Cys; cysteine; CYP450; cytochrome P450; DAD; diode array detector; GSH; glutathione; GST; glutath
مقالات ISI منطقه تحت منحنی غلظت-زمان (ترجمه نشده)
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Keywords: منطقه تحت منحنی غلظت-زمان; AUC; area under the concentration-time curve; AST; aspartate transaminase; ALT; alanine transaminase; BCRP; breast cancer resistance protein; BEI; biliary excretion index; CL/F; oral clearance; Clbiliary; in vitro biliary clearance; ER; Efflux Ratio; LCâ
Keywords: منطقه تحت منحنی غلظت-زمان; AUC; area under the concentration-time curve; BN; benalaxyl; CE; capillary electromigration techniques; CL; clearance; CLH; hepatic clearance; CLint; intrinsic clearance; DC; diclofop; DM; diclofop-methyl; DN; diniconazole; E; hepatic extraction rate; ET;
Quantitative estimation of cholinesterase-specific drug metabolism of carbamate inhibitors provided by the analysis of the area under the inhibition-time curve
Keywords: منطقه تحت منحنی غلظت-زمان; AChE; acetylcholinesterase (EC 3.1.1.7); ADME; absorption, distribution, metabolism, excretion; AUC; area under the concentration-time curve; AUIC; area under the inhibition-time curv; BChE; butyrylcholinesterase (EC 3.1.1.8); BTCh; butyrylthiocholine; DT
Keywords: منطقه تحت منحنی غلظت-زمان; CAD; coronary artery diseases; DIC; disseminated intravascular coagulation, I/R, ischemia/reperfusion; MPI; myocardial perfusion imaging; SCI; spinal cord injury; ED; erectile dysfunction; AUC; area under the concentration-time curve; cAMP; cyclic adenosi
Keywords: منطقه تحت منحنی غلظت-زمان; Hydroxyurea (HU); Sickle cell anemia (SCA); Pharmacometrics; D-optimal design; Bayesian individualized dosing; SCA; sickle cell anemia; MTD; maximum tolerated dose; PK; pharmacokinetics; PD; pharmacodynamics; AUC; area under the concentration-time curve;
Keywords: منطقه تحت منحنی غلظت-زمان; physiologically based pharmacokinetic modeling; transporters; hepatobiliary disposition; hepatic metabolism; mathematical model; AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; CYP; cytochrome P450 enzyme; CL; clearance;
Keywords: منطقه تحت منحنی غلظت-زمان; AS; aqueous solution; AUC; area under the concentration-time curve; Cmax; peak concentration; cy5.5; Cyanine5.5 NHS ester; DLS; dynamic light scattering; EE; entrapment efficiencies; EL; Chremophor® EL; EO; ethyl oleate; HPLC; high-performance liquid chr
Keywords: منطقه تحت منحنی غلظت-زمان; AE; adverse event; AUC; area under the concentration-time curve; BMI; body mass index; C150; canagliflozin 150Â mg; C300; canagliflozin 300Â mg; CI; confidence interval; CRC; clinical research center; CV; coefficient of variation; FPG; fasting plasma gluc
Optimization and application of an HPLC method for quantification of inosine-5â²-monophosphate dehydrogenase activity as a pharmacodynamic biomarker of mycophenolic acid in Chinese renal transplant patients
Keywords: منطقه تحت منحنی غلظت-زمان; Mycophenolic acid; Inosine 5â²-monophosphate dehydrogenase; High performance liquid chromatography; Pharmacodynamic biomarker; AEC; area under enzyme activity-time curve; AMP; adenosine monophosphate; AUC; area under the concentration-time curve; BSA; bo
Effects of Paullinia cupana extract on lamotrigine pharmacokinetics in rats: A herb-drug interaction on the gastrointestinal tract with potential clinical impact
Keywords: منطقه تحت منحنی غلظت-زمان; Herb-drug interaction; Lamotrigine; Paullinia cupana; Rats; AED; antiepileptic drug; AUC; area under the concentration-time curve; AUC0-24; AUC from time zero to 24â¯h; AUC0-t; AUC from time zero to the last measurable concentration; AUC0-â; AUC from t
Evaluation of a novel micro-sampling device, Mitraâ¢, in comparison to dried blood spots, for analysis of praziquantel in Schistosoma haematobium-infected children in rural Côte d'Ivoire
Keywords: منطقه تحت منحنی غلظت-زمان; Cmax; maximal blood concentration; Tmax; time needed to reach maximal blood concentration; T1/2; half life of the drug; AUC; area under the concentration-time curve; DBS; dried blood spots; PZQ; praziquantel; PK; pharmacokinetics; SAC; school-aged childre
Suitability of the AUC Ratio as an Indicator of the Pharmacokinetic Advantage in HIPEC
Keywords: منطقه تحت منحنی غلظت-زمان; Clinical pharmacokinetics; Simulations; Cancer chemotherapy; Absorption; Mathematical models; Clearance; HIPEC; hyperthermic intraoperative peritoneal chemotherapy; iv; intravenous; PKA; pharmacokinetic advantage; ka; absorption rate constant; ka_app; app
Differential effects of liver steatosis on pharmacokinetic profile of two closely related hepatoselective NO-donors; V-PYRRO/NO and V-PROLI/NO
Keywords: منطقه تحت منحنی غلظت-زمان; ALT; alanine transaminase; ASP; aspartate transaminase; AUC; area under the concentration-time curve; C0; initial concentration; Km; Michaelis-Menten constant; LC/MS/MS; liquid chromatography coupled to tandem mass spectrometry; LDH; lactate dehydrogenase
Measurement of micronuclei and internal dose in mice demonstrates that 3-monochloropropane-1,2-diol (3-MCPD) has no genotoxic potency in vivo
Keywords: منطقه تحت منحنی غلظت-زمان; 3-MCPD; Micronucleated erythrocytes in peripheral blood; Hb adducts; Genotoxicity; In vivo; Mice; ACN; acetonitrile; AUC; area under the concentration-time curve; diHOPrVal; N-(2,3-dihydroxypropyl)-valine; FITC; fluorescein isothiocyanate; fMPCE; frequen
Prediction of human percutaneous absorption from in vitro and in vivo animal experiments
Keywords: منطقه تحت منحنی غلظت-زمان; PK; pharmacokinetic; Vd; steady-state volume of distribution; CL; total body clearance; OECD; the Organization for Economic Co-operation and Development; FDA; U.S. Food and Drug Administration; EMA; European Medicines Agency; IV; intravenous; LC-MS/MS;
Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats
Keywords: منطقه تحت منحنی غلظت-زمان; (-)-Epigallocatechin gallate; Licarbazepine; Oxcarbazepine; P-glycoprotein; Pharmacokinetics; Silymarin; AEDs; antiepileptic drugs; AUC; area under the concentration-time curve; AUC0-t; AUC from time zero to the last sampling time; AUC0-â; AUC from time
Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations
Keywords: منطقه تحت منحنی غلظت-زمان; AUC; Area under the concentration-time curve; BBB; Blood-brain barrier; Cact,blood; Total radioactivity measured in blood; Cact,brain(PET); Blood corrected radioactive concentrations in brain; Cact,injection; Concentration of injected radioactivity; Cact,
Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein
Keywords: منطقه تحت منحنی غلظت-زمان; Cucurbitacin E; CYP3A; P-glycoprotein; Hepatotoxicity; Drug-drug interactions; CuE; cucurbitacin E; P-gp; p-glycoprotein; Cmax; the maximum serum concentration; AUC; area under the concentration-time curve; CL; clearance; Vd; volume of distribution; t1/2;
P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine
Keywords: منطقه تحت منحنی غلظت-زمان; ABC; ATP-binding cassette; AUC; area under the concentration-time curve; BBB; the blood-brain barrier; BPB; the blood-placental barrier; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; ABCB1; the first member of subfamily B of the ABC transp
Maternal-fetal transfer of indocyanine green across the perfused human placenta
Keywords: منطقه تحت منحنی غلظت-زمان; a.u.; arbitrary units; AUC; area under the concentration-time curve; CI; clearance index; FA; fetal artery; FV; fetal vein; βhCG; human chorionic gonadotropin beta; DMSO; dimethylsulfoxide; ICG; indocyanine green; MDR; multidrug resistance protein; %MFT;
Pharmacokinetics, tissue distribution and excretion of 40 kDa PEG and PEGylated rFVIII (N8-GP) in rats
Keywords: منطقه تحت منحنی غلظت-زمان; AUC; area under the concentration-time curve; CL; total plasma clearance; CLd; intercompartmental distribution clearance; C0; concentration at time zero; CMP-NAN; cytidine-5â²-monophospho-N-acetylneuraminic acid; CNS; central nervous system; EDTA; ethyle
Gastrodia elata and epilepsy: Rationale and therapeutic potential
Keywords: منطقه تحت منحنی غلظت-زمان; Epilepsy; Gastrodia elata; Gastrodin; Phenolic compounds; Anticonvulsant properties; AED; antiepileptic drug; AUC; area under the concentration-time curve; Cmax; peak plasma concentration; CNS; central nervous system; ED50; median effective dose; G. elata
The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice
Keywords: منطقه تحت منحنی غلظت-زمان; ABC; ATP-binding cassette; AUC; area under the concentration-time curve; DDI; drug-drug interactions; E2G; estradiol 17β-d-glucuronide; i.v.; intravenous; OATP; organic anion-transporting polypeptide; TKI; tyrosine kinase inhibitor; UGT1A1; UDP-glucuro
The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study
Keywords: منطقه تحت منحنی غلظت-زمان; ACS; acute coronary syndrome; ADP; adenosine diphosphate; AM; active metabolite; AUC; area under the concentration-time curve; BMI; body mass index; BSA; body surface area; BW; body weight; CAD; coronary artery disease; Clop; clopidogrel; Cmax; maximum co
Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs
Keywords: منطقه تحت منحنی غلظت-زمان; AUC; area under the concentration-time curve; Abile; amount excreted in bile; Aurine; amount excreted in urine; Aprot; microsomal content; Atot.I; total amount of fexofenadine excreted into the jejunal segment; Atot.urine; total amount of fexofenadine exc
Calcineurin Inhibitor Treatment of Intravenous Immunoglobulin-Resistant Kawasaki Disease
Keywords: منطقه تحت منحنی غلظت-زمان; AUC; Area under the concentration-time curve; CRP; C-reactive protein; CSA; Cyclosporine; IL; Interleukin; IV; Intravenous; IVIG; Intravenous immunoglobulin; KD; Kawasaki disease; NFAT; Nuclear factor of activated T cell; SNP; Single nucleotide polymorphi
In Vivo Evaluation of Cisplatin-loaded Superabsorbent Polymer Microspheres for Use in Chemoembolization of VX2 Liver Tumors
Keywords: منطقه تحت منحنی غلظت-زمان; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under the concentration-time curve; HAI; hepatic arterial infusion; HCC; hepatocellular carcinoma; SAP; superabsorbent polymer;
Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: Essential roles of CYP2A5 and target-tissue metabolic activation
Keywords: منطقه تحت منحنی غلظت-زمان; P450 or CYP; cytochrome P450; CPR; NADPH-cytochrome P450 reductase; GC; gas chromatography; MS; mass spectrometry; HPLC; high-performance liquid chromatography; AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; Tmax; time w
Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum
Keywords: منطقه تحت منحنی غلظت-زمان; AUC; area under the concentration-time curve; BBM; brush-border membrane; C/D ratio; concentration/oral dose ratio; CYP3A; cytochrome P450 IIIA; DAPI; 4â²,6-diamidino-2-phenylindole; GAPDH; glyceraldehydes 3-phosphate dehydrogenase; MDR1; multidrug resis