
Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor α liver injury
Keywords: TNFα, tumor necrosis factor α; CYP2E1, cytochrome P4502E1; PY, pyrazole; ROS, reactive oxygen species; ASK-1, apoptosis signal-regulating kinase-1; Trx, thioredoxin; MAPK, mitogen-activated protein kinase; MAP3K, MAP kinase kinase kinase; MKK, MAP kinase