Keywords: ASM، عضله صاف راه هوایی; ASM, airway smooth muscle; EGFR, epidermal growth factor receptor; ICS, inhaled corticosteroid; LABA, long-acting β-agonist; MLCK, myosin light chain kinase; TGF-β, transforming growth factor-β
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Keywords: ASM، عضله صاف راه هوایی; ANOVA, analysis of variance; ASM, airway smooth muscle; AUC, area under the curve; BHR, hyperresponsiveness; CD14, cluster of differentiation 14; CTCF, corrected total cell fluorescence; DAPI, 4′,6-diamidino-2-phenylindole; EFS, electrical field stimulati
Keywords: ASM، عضله صاف راه هوایی; Hormone; Estrogen; Progesterone; Testosterone; Airway; Alveoli; Asthma; COPD; Pulmonary fibrosis3β-HSD, 3β-hydroxysteroid dehydrogenase; AR, androgen receptor; ERE, estrogen response elements; ASM, airway smooth muscle; cAMP, cyclic adenosine monophosphat
Interaction between corticosteroids and muscarinic antagonists in human airways
Keywords: ASM، عضله صاف راه هوایی; Airway smooth muscle; Asthma; ICS; LAMA; Drug interactionANOVA, analysis of variance; ASM, airway smooth muscle; BHR, bronchial hyperresponsiveness; BI, Bliss Independence; cAMP, cyclic adenosine monophosphate; COPD, chronic obstructive pulmonary disease;
Exhaled matrix metalloproteinase-9 (MMP-9) in different biological phenotypes of asthma
Keywords: ASM، عضله صاف راه هوایی; NO, Nitric oxide; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; MMP-9, matrix metalloproteinase-9; ASM, airway smooth muscle; TIMPs, tissue inhibitors of metalloproteinases; BAL, broncho-alveolare lavageAirways; Asthma; MMP-9;
Vitamin D deficiency and severe asthma
Keywords: ASM، عضله صاف راه هوایی; Vitamin D; Severe asthma; Exacerbation; Airway remodeling; Steroid resistanceADAM33, ADAM metallopeptidase domain 33; ASM, airway smooth muscle; CRTAM, class I major histocompatibility complex-restricted T cell-associated molecule; CXCL12, chemokine (C-X-
Functional phenotype of airway myocytes from asthmatic airways
Keywords: ASM، عضله صاف راه هوایی; Airway smooth muscle; Vascular smooth muscle; Asthma; Extracellular matrix; Animal modelsAHR, airway hyperresponsiveness; ASM, airway smooth muscle; C/EBP α, CCAAT/enhancer binding protein α; CTGF, connective tissue growth factor; ECM, extracellular matri
In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and a
Keywords: ASM، عضله صاف راه هوایی; PL-3994; Natriuretic peptide receptors; Atrial natriuretic peptide; Brain natriuretic peptide; Neutral endopeptidase sensitivity; BronchodilatorANP, atrial natriuretic peptide; ASM, airway smooth muscle; BNP, brain natriuretic peptide; BSA, bovine serum a
Bronchial epithelium as a target for innovative treatments in asthma
Keywords: ASM، عضله صاف راه هوایی; Asthma; Epithelial cells; Airways; Treatment; Structural changesAch, Acetylcholine; AHR, Airway hyperresponsiveness; ASM, Airway smooth muscle; BAL, Bronchoalveolar lavage; BEC, Bronchial epithelial cell; CF, Cystic fibrosis; CFTR, Cystic fibrosis transme
Effects of decorin and biglycan on human airway smooth muscle cell adhesion
Keywords: ASM، عضله صاف راه هوایی; ASM, airway smooth muscle; Bgn, biglycan; Col I, collagen type I; Dcn, decorin; EGFR, epidermal growth factor receptor; ECM, extracellular matrix; F-, filamentous; G-, globular; FAK, focal adhesion kinase; GFR, growth factor receptor; HASMC, human airway
Isoprostanes and asthma
Keywords: ASM، عضله صاف راه هوایی; ARE, antioxidant response element; ASM, airway smooth muscle; COX, Cyclooxygenase; EFS, electrical field stimulation; F2-isoP, F2-isoprostanes; GC, Gas chromatography; HDM, House dust mite; ICS, inhaled corticosteroids; LC, liquid chromatography; MS, mass
Evidence of a genetic contribution to lung function decline in asthma
Keywords: ASM، عضله صاف راه هوایی; Asthma; airway remodeling; genetic susceptibility; lung function declineADAM33, A disintegrin and metalloproteinase domain 33; AGER, Advanced glycosylation end-product receptor; AHR, Airways hyperresponsiveness; ASM, Airway smooth muscle; ERK, Extracellul
What effect does asthma treatment have on airway remodeling? Current perspectives
Keywords: ASM، عضله صاف راه هوایی; Asthma; asthma treatment; remodeling; corticosteroids; inflammation; anti-IgE; omalizumab; anti–TNF-α; golimumab; anti–IL-5; mepolizumabAHR, Airway hyperresponsiveness; ASM, Airway smooth muscle; ECM, Extracellular matrix; ICS, Inhaled corticosteroid; LAB
Remodeling in asthma
Keywords: ASM، عضله صاف راه هوایی; Asthma; remodeling; airway smooth muscle; fibrosis; corticosteroidAHR, Airway hyperresponsiveness; ASM, Airway smooth muscle; CAM, Cellular adhesion molecule; CT, Computed tomography; ECM, Extracellular matrix; ICAM-1, Intercellular adhesion molecule 1; I
Airway remodeling in asthma: New mechanisms and potential for pharmacological intervention
Keywords: ASM، عضله صاف راه هوایی; ADAM, A disintegrin and metalloprotease; ASM, airway smooth muscle; BALF, Bronchoalveolar lavage fluid; BHR, bronchial hyperresponsiveness; [Ca2+]i, concentration of free Ca2+ in the cytosol; CaMK-IV, calcium/calmodulin-dependent protein kinase IV; CCL, C
Bronchial hyperresponsiveness to histamine correlates with airway remodelling in adults with asthma
Keywords: ASM، عضله صاف راه هوایی; Bronchial asthma; Bronchial hyperresponsiveness; Acetylcholine; Histamine; Airway remodelling; Eosinophilic inflammationACh, acetylcholine; ASM, airway smooth muscle; BHR, bronchial hyperresponsiveness; FEV1, forced expiratory volume in 1 s; FP, fluticaso
Allergen-induced asthma in C57Bl/6 mice: Hyper-responsiveness, inflammation and remodelling
Keywords: ASM، عضله صاف راه هوایی; ASM, airway smooth muscle; BAL, bronchoalveolar lavage; Gti, damping; Hti, elastance; I, inertance; MCh, methacholine; OVA, ovalbumin; P, pressure; Pbm, basement membrane perimeter; PEEP, positive end expiratory pressure; Ptp, transpulmonary pressure; Raw
Targeting the airway smooth muscle for asthma treatment
Keywords: ASM، عضله صاف راه هوایی; ASM, airway smooth muscle; BALF, bronchoalveolar lavage fluid; COPD, chronic obstructive pulmonary disease; EMT, epithelial–mesenchymal transition; FEV1, forced expiratory volume in 1 s; IL, interleukin; MAPK, mitogen-activated protein kinases; MC, mast c
The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma
Keywords: ASM، عضله صاف راه هوایی; AHR, airway hyperresponsiveness; ASM, airway smooth muscle; BAL, bronchial lavage fluid; BDNF, brain-derived neurotrophic factor; CCN, cysteine-rich 61 (CYR61), CTGF, nephroblastoma overexpressed (NOV); CTGF, connective tissue growth factor; ECM, extracel
Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease
Keywords: ASM، عضله صاف راه هوایی; NF-κB; IKK-β; Asthma; COPD; Inflammation; LungCOPD, chronic obstructive pulmonary disease; CS, cigarette smoke; GC, corticosteroid; NF-κB, nuclear factor-κB; AHR, airway hyperreactivity; ASM, airway smooth muscle; PEF, peak expiratory flow; FEV, forced ex
Targeting TNF-α: A novel therapeutic approach for asthma
Keywords: ASM، عضله صاف راه هوایی; Asthma; refractory asthma; TNF-α; mast cells; airway smooth muscleAHR, Airway hyperresponsiveness; ASM, Airway smooth muscle; mTNF-α, Membrane TNF-α
Obesity and asthma: Possible mechanisms
Keywords: ASM، عضله صاف راه هوایی; Functional residual capacity; airway closure; leptin; adiponectin; macrophageAHR, Airway hyperresponsiveness; ASM, Airway smooth muscle; ATM, Adipose tissue macrophage; BMI, Body mass index; FRC, Functional residual capacity; GERD, Gastroesophageal reflux
Increased sputum and bronchial biopsy IL-13 expression in severe asthma
Keywords: ASM، عضله صاف راه هوایی; Severe asthma; IL-13; sputum; bronchus; airway smooth muscle; eosinophiliaACQ, Juniper Asthma Control Questionnaire; AHR, Airway hyperresponsiveness; ASM, Airway smooth muscle; GINA, Global Initiative for Asthma
Essential role of IFNβ and CD38 in TNFα-induced airway smooth muscle hyper-responsiveness
Keywords: ASM، عضله صاف راه هوایی; Allergic asthma; Cytokine; Airway smooth muscle; Inflammation; Calcium signaling; HypercontractilityAf, Aspergillus fumigatus; AHR, airway hyper-responsiveness; ASM, airway smooth muscle; BK, bradykinin; (Ca2+)I, intracellular calcium; Ch, carbachol; IFN,
Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes
Keywords: ASM، عضله صاف راه هوایی; Epithelial injury; airway smooth muscle; mast cells; microvascular permeability; eicosanoids; β2-agonistsAHR, Airway hyperresponsiveness; ASL, Airway surface liquid; ASM, Airway smooth muscle; CC16, 16-kd Clara cell protein; EIB, Exercise-induced bronchoc
Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization
Keywords: ASM، عضله صاف راه هوایی; 3D, three-dimensional; Ad12SV40, adenovirus 12-simian virus 40 hybrid virus; AHR, airway hyperresponsiveness; APCs, antigen-presenting cells; ASM, airway smooth muscle; ATCC, American Type Culture Collection; BAL, bronchoalveolar lavage; BECs, bronchial e
Understanding the mechanisms of viral induced asthma: New therapeutic directions
Keywords: ASM، عضله صاف راه هوایی; AAD, allergic airways disease; AHR, airway hyperresponsiveness; APC, antigen-presenting cell; ASM, airway smooth muscle; BALF, broncho-alveolar lavage fluid; BEC, bronchoepithelial cell; bFGF, basic fibroblast growth factor; CAM, Cellular adhesion molecul
Pharmacological actions of isoprostane metabolites and phytoprostanes in human and bovine pulmonary smooth muscles
Keywords: ASM، عضله صاف راه هوایی; ASM, airway smooth muscle; CCh, carbachol; EP, prostaglandin e-selective prostanoid receptor; FP, prostaglandin F2(-selective prostanoid receptor; 15-F2t-IsoP, 8-iso-prostaglandin F2a or IPF2A-III, L-NNA; N-ω-nitro-l-arginine; PASM, pulmonary arterial smo
Downregulation of a disintegrin and metalloproteinase 33 by IFN-γ in human airway smooth muscle cells
Keywords: ASM، عضله صاف راه هوایی; Asthma; airway remodeling; airway smooth muscle; a disintegrin and metalloproteinase 33; IFN-γ; extracellular signal-regulated kinase pathwayADAM, A disintegrin and metalloproteinase; ASM, Airway smooth muscle; BHR, Bronchial hyperresponsiveness; COL1A1,
Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis
Keywords: ASM، عضله صاف راه هوایی; ABC, ATP binding cassette; Ag, antigen; AHR, airway hyperresponsiveness; ASM, airway smooth muscle; BAL, bronchoalveolar lavage; BMMC, bone marrow-derived mast cells; COX, cyclooxygenase; ER, endoplasmic reticulum; ERK, extracellular signal regulated kina
The allergic cascade: Review of the most important molecules in the asthmatic lung
Keywords: ASM، عضله صاف راه هوایی; ADAM, a disintegrin and metalloproteinase; AHR, airway hyperresponsiveness; APCs, antigen-presenting cells; ASM, airway smooth muscle; BAL, bronchoalveolar lavage; BECs, bronchial epithelial cells; bFGF, basic fibroblast growth factor; CCL, CC-chemokine l
A novel therapeutic target in various lung diseases: Airway proteases and protease-activated receptors
Keywords: ASM، عضله صاف راه هوایی; APC, activated protein C; ASM, airway smooth muscle; CTGF, connective tissue growth factor; EGFR, epidermal growth factor receptor; HAT, human airway trypsin-like protease; HPAEC, human pulmonary artery endothelial cells; IL, interleukin; LPS, lipopolysac
The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells
Keywords: ASM، عضله صاف راه هوایی; ASM, airway smooth muscle; Gi, inhibitory G-protein; Giα, alpha sub-unit of Gi; GPCR, G-protein coupled receptor; HEK 293, human embryonic kidney 293; IP, immunoprecipitation; MAPK, mitogen-activated protein kinase; PDGF, platelet-derived growth factor; P
Airway remodelling in asthma: Current understanding and implications for future therapies
Keywords: ASM، عضله صاف راه هوایی; AAD, allergic airways disease; ADAM33, a disintegrin and metalloprotease 33; AHR, airway hyperresponsiveness; ASM, airway smooth muscle; BALF, bronchoalveolar lavage fluid; BM, basement membrane; C/EBPα, CCAAT/enhancer binding protein α; COPD, chronic obs
Structural Changes in Airway Diseases : Characteristics, Mechanisms, Consequences, and Pharmacologic Modulation
Keywords: ASM، عضله صاف راه هوایی; airway inflammation; airway remodeling; antiasthmatic therapy; asthma; COPD; corticosteroids; cystic fibrosisADAM-33, a disintegrin and metalloproteinase; AHR, airway hyperresponsiveness; ASM, airway smooth muscle; bFGF, basal fibroblast-derived growth fa
Obesity and asthma
Keywords: ASM، عضله صاف راه هوایی; Atopy; Airway responsiveness; Inflammation; Leptin; Adiponectinβ2-AR, β2-adrenoceptor; AHR, airway hyperresponsiveness; ASM, airway smooth muscle; BALF, bronchoalveolar lavage fluid; BMI, body mass index; CDC, Centers for Disease Control and Prevention; C