دانلود مقالات ISI درباره ATM، Ataxia-telangiectasia جهش یافته است + ترجمه فارسی

Yet another job for Dna2: Checkpoint activation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; 9–1–1, human Rad9, Rad1, Hus1 (yeast Ddc1, Rad17, Mec3) checkpoint clamp; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3–related; ATRIP, ATR interacting protein; DSB, double-strand break; dsDNA, double-stranded DNA; ssDNA, single-stranded DNA; FEN1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Novel characteristics of CtIP at damage-induced foci following the initiation of DNA end resection

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; DNA double strand break repair; DNA end resection; CtIP; PhosphorylationHR, homologous recombination; NHEJ, non-homologous end joining; ATM, ataxia-telangiectasia mutated; ATR, ataxia-telangiectasia mutated and Rad3 related; DSB, double strand break; SSD,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The role of oxidative DNA damage in radiation induced bystander effect

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; AP-1, activation protein-1; ARF, alternative reading frame; ATM, ataxia-telangiectasia mutated; ATR, ataxia-telangiectasia mutated Rad3-related; BER, base excision repair; Cdc6, cell division cycle 6; cfDNA, circulating oxidized DNA; COX-2, cyclooxygenase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

O-GlcNAcylation of eIF2α regulates the phospho-eIF2α-mediated ER stress response

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; 1DLC–MS/MS, one-dimensional liquid chromatography/tandem mass spectrometry; ATF4, activating transcription factor 4; ATM, ataxia-telangiectasia mutated; CHOP, C/EBP homologous protein; CID, collision-induced dissociation; DTT, dithiothreitol; eIF2α, eukar

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Redox control of protein degradation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; Aβ, amyloid beta; AMPK, AMP activated protein kinase; ASK1, apoptosis signal-regulating kinase 1; ATG4, autophagy related protein 4; ATM, ataxia-telangiectasia mutated; BCL-2, B-cell lymphoma 2; CMA, chaperone mediated autophagy; ER, endoplasmic reticulum

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Dermatologic manifestations of ataxia-telangiectasia syndrome

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ataxia-telangiectasia; ATM mutation; papulosquamous rash; pigmentation anomaliesA-T, ataxia-telangiectasia; ATM, ataxia-telangiectasia mutated; CALM, café-au-lait macules

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; γH2A.X, H2A.X phosphorylation on Ser-139; MSeA, methylseleninic acid; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NPC, Nutritional Prevention of Cancer; pATM Ser-1981, phosphorylation of ATM on Se

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

A new mechanism to ensure integration during LINE retrotransposition: A suggestion from analyses of the 5′ extra nucleotides

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; bp, base pair; DSB, DNA double-strand break; kbp, kilo base pair; LINE, long interspersed element; mRNA, messenger RNA; NHEJ, non-homologous end joining; ORF, open reading frame; RT, reverse transcriptase; TPRT, target-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; Chk1; Chk1inhibitor; AZD7762; Radiosensitivity; DNA damage checkpointDSB, double-stranded DNA break; Chk1, checkpoint kinase 1; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; IR, ionizing radiation; MBT, metastatic brain tumor; shRNA, smal

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; Cdk, cyclin-dependent kinase; ATM, ataxia-telangiectasia mutated; ATR, ATM-and Rad3-related; Chk1, checkpoint kinase 1; UV, ultravioletChk1; Cdk; S/M checkpoint; G2/M checkpoint; Cell cycle

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; MSeA, methylseleninic acid; MTT, 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; NPC, Nutritional Prevention of Cancer Trial; pATM Ser-1981, phosphorylation of ATM on Ser-1981; ROS, reactive oxygen species

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Detection of DNA damage in oocytes of small ovarian follicles following phosphoramide mustard exposures of cultured rodent ovaries in vitro

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; Ab, antibody; ATM, ataxia-telangiectasia mutated; ATR, ATM-related; CPA, cyclophosphamide; DMSO, dimethyl sulfoxide; DNA-PK, DNA-dependent protein kinases; DSB, double-strand break; IHC, immunohistochemistry; IR, ionizing radiation; PIKK, phosphatidylinos

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; SSCs, spermatogonial stem cells; DSBs, DNA double-strand breaks; DNA-PK, DNA protein kinase; DNA PKcs, catalytic subunit of the DNA protein kinase; ATM, Ataxia-telangiectasia mutated; MDC1, mediator of DNA damage checkpoint protein 1; 53BP1, p53 binding p

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; NF-κB, nuclear factor B; ATM, ataxia-telangiectasia mutated; IR, ionising radiation; DSB, double strand break; HRR, homologous recombination repair; NHEJ, non-homologous recombination repairNF-κB; Breast cancer; ATM; Ionizing radiation; Apoptosis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; A-T, ataxia-telangiectasia; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; LIG, ligase; DSB, double-strand break; FANC, Fanconi anemia; IR, ionizing radiation; NBN, nibrin; NBS, Nijmegen breakage syndrome; NHEJ, nonhomologous end joiningγ-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Nitric oxide mediated DNA double strand breaks induced in proliferating bystander cells after α-particle irradiation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; 53BP1, p53 binding protein 1; BRCT, BRCAI C-Terminal; CHO, Chinese hamster ovary; DSB, DNA double strand break; FCM, flow cytometry; LET, linear energy transfer; MN, micronuclei; NO, nitric oxide; NOS, nitric oxide synt

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Prion protein: From physiology to cancer biology

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ABC transporter, ATP-Binding Cassette transporter; ADAM, a disintegrin and metalloprotease; AKT, v-akt murine thymoma viral oncogene homolog; ATM, ataxia-telangiectasia mutated; Bax, Bcl-2-associated X protein; Bcl-2, B-cell leukemia/lymphoma 2; BCL-XL/Bc

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2010 سفارش ترجمه

The synapsins: Key actors of synapse function and plasticity

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; BDNF, brain-derived neurotrophic factor; CaMK, Ca2+/calmodulin-dependent protein kinase; DRE, delayed response enhancement; eIPSCs, evoked inhibitory post-synaptic currents; eEPSC, evoked excitatory post-synaptic curren

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2010 سفارش ترجمه

DNA Double-Strand Break Formation upon UV-Induced Replication Stress Activates ATM and DNA-PKcs Kinases

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; ATR, ataxia-telangiectasia and Rad3 related; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; CPD, cyclobutane pyrimidine dimer; NER, nucleotide excision repair; DSB, double-strand break; ssDNA, single-stranded

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ABC, ATP-binding cassette; Ad, adenovirus; ATM, ataxia-telangiectasia mutated; BM, bone marrow; CDK, cyclin-dependent kinase; CK, cytokeratine; COX-2, clyooxygenase 2; CXCR4, CXC chemokine receptor 4; EGF, epidermal growth factor; EGFR, epidermal growth f

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2009 سفارش ترجمه

Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; ATR, ATM- and Rad3-related; Cdk, cyclin-dependent kinase; HU, hydroxyurea; UV, ultraviolet; AS, asynchronous; GST, glutathione S-transferase; WT, Chk1 wild type; S286A, Chk1 mutated at Ser286 to Ala; S301A, Chk1 mutated

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; AT, ataxia-telangiectasia; Atm, ataxia-telangiectasia mutated; CTMIO, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl; DSBs, double-strand breaks; HPLC, high performance liquid chromatography; GSH, glutathione; NAC, N-acetyl-l-cysteine; p, pink-eyed dilu

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: Involvement of p53 phosphorylation and acetylation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; AhR, aryl hydrocarbon receptor; ANF, α-naphthoflavone; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; BaP, benzo[a]pyrene; BPDE-I, r-7,t-8-dihydrodiol-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene; CYP1A1, cytochrome P450 1A1; DNA-PK, DNA-d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Insulin-like growth factor-1 attenuates cisplatin-induced γH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; ATR, ATM-Rad3-related; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; DSB, double-strand break; HR, homologous recombination-directed DNA repair; IGF-1, insulin-like growth factor-1; IGF-1R, IGR-1 receptor, I

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; DNA damage; ICRF-193; Topoisomerase II; Cell cycle; G2 arrestA-T, ataxia-telangiectasia; ATM, ataxia-telangiectasia mutated; ATR, ATM- and Rad3-related; DSB, DNA double-strand breaks; IR, ionizing radiation; ATR-kd, kinase-dead ATR; LMP, low melting point

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

NF-κB-mediated adaptive resistance to ionizing radiation

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; ERK, extracellular signal-regulated kinase; FIR, fractionated ionizing radiation; GADD45β, growth arrest DNA damage gene 45β; IκB, inhibitor-κB; IKK, IκB kinase; IL-1, interleukin-1; IR, ionizing radiation; JNK, c-Jun N

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

PKC inhibitor Go6976 induces mitosis and enhances doxorubicin-paclitaxel cytotoxicity in urinary bladder carcinoma cells

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; ATR, ataxia-telangiectasia mutated- and Rad3-related; BSA, bovine serum albumin; cdc, cell division cycle; DMEM, Dulbecco’s modified Eagle’s medium; DMSO, dimethyl sulfoxide; ECL, enhanced chemiluminescence; FACS, fluor

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; CHX, cycloheximide; CK2, casein kinase-2; CKIP-1, casein kinase-2 interacting protein-1; LZPR, leucine zipper and proline-rich domain; PH, pleckstrin homology; PI3K, phosphoinositol-3-kinaseCKIP-1; ATM; p53 degradation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; Plk3, polo-like kinase 3; ATM, ataxia-telangiectasia mutated; IR, ionizing radiation; FPLC, fast performance liquid chromatography; GFP, green fluorescence proteinPlk3; Chk2; ATM; DNA damage; Priming phosphorylation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Effect of the reduction of superoxide dismutase 1 and 2 or treatment with α-tocopherol on tumorigenesis in Atm-deficient mice

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; SOD, superoxide dismutases; ROS, reactive oxygen species; AT, ataxia-telangiectasia; Atm, ataxia-telangiectasia mutated; C-ACO, cytosolic aconitase; M-ACO, mitochondrial aconitase; HCC, hepatocellular carcinoma; Δψm, mitochondrial membrane potential; HX,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

UV-induced RPA phosphorylation is increased in the absence of DNA polymerase η and requires DNA-PK

Keywords: ATM، Ataxia-telangiectasia جهش یافته است; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; ATRIP, ATR-interacting protein; CPD, cyclobutane pyrimidine dimer; DNA-PK, DNA-dependent protein kinase; Polη, polymerase η; RPA, replication protein A; XPV, xeroderma pigmentosum variantPolη;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه