
Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK
Keywords: Ar, aryl; ATP, Adenosine-5′-triphosphate; AUC, area under the curve; BA, bioavailability; CYP, Cytochrome P450; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM, dichloromethane; DIPEA, diisopropylethylamine; Δ, heat; DME, 1,2-dimethoxyethane; DMF, N,N-dimeth