Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase
Keywords: BCNU، 1،3-bis (2-chloroethyl) -1-nitrosourea; CENUs, chloroethylnitrosoureas; ACNU, 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea; BCNU, 1,3-bis(2-chloroethyl)-1-nitrosourea; CCNU, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; me-CCNU, 1-(2-chloroethyl)-3-(4-methyl-cycloh