Liquid chromatography–tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies
Keywords: BCR, B-cell antigen receptor; BSA, bovine serum albumin; BTK, Bruton’s tyrosine kinase; CHMP, Committee for Medicinal Products for Human Use; DHI, dhihydrodiol-ibrutinib; DMSO, dimethyl Sulphoxide; EMA, European Medicines Agency; ErbB2, receptor tyrosine-