Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; 3′ UTRs, 3′ untranslated regions; 4E-BP1, 4E binding protein 1; BCRP, breast cancer resistance protein; BMP, bone morphogenetic protein; CNTF, ciliary neurotrophic factor; CIITA, Class II Transactivator; CPEB1, cytoplasmic polyadenylation element-binding
مقالات ISI Bcrp، پروتئین مقاوم در برابر سرطان پستان (ترجمه نشده)
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Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC transporter, ATP-binding cassette transporter; MDR, multidrug resistance; MRP, multidrug resistance-associated protein; cMOAT, canalicular multispecific organic anion transporter; BCRP, breast cancer resistance protein; MXR, mitoxantrone resistance pr
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP-binding cassette; AhR, aryl hydrocarbon receptor; ALDH3A1, aldehyde deshydrogenase 3A1; BCRP, breast cancer resistance protein; BSEP, bile salt export pump; BSP, bromosulfophtalein; CCK8, cholecystokinin octapeptide sulphated; CF, carboxy-2.7-dic
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ADR, adverse drug reaction; ABC, ATP-binding cassette; AUC, area under plasma concentration versus time curve; BCRP, breast cancer resistance protein; CAR, constitutive androstane receptor; CE, capillary electrophoresis; CHM, Chinese herbal medicine; CL,
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP Binding Cassette; ALK, activin receptor-like kinase; BBB, blood–brain barrier; BCRP, Breast Cancer Resistance Protein; CNS, central nervous system; GSH, glutathione; GSSG, glutathione disulfide; JAM, junctional adhesion molecule; MAGUK, membrane-
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Flavonoid; Quercetin; Antioxidant; Anthracycline; Cardiotoxicity; Multidrug resistanceAIF, Apoptosis-inducing factor; BCRP, Breast cancer resistance protein; CDK2, Cyclin-dependent kinase 2; CHF, Congestive heart failure; DMBA, Dimethyl benz(a)anthracene;
Pharmacokinetics and tissue distribution of 5,7-dimethoxyflavone in mice following single dose oral administration
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; 5,7-DMF, 5,7-Dimethoxyflavone; PK, pharmacokinetic; LC–MS/MS, Liquid chromatography–tandem mass spectrometry; CYP, Cytochrome P450; P-gp, P-glycoprotein; MRP, multidrug resistance associated-proteins; BCRP, Breast Cancer Resistance Protein; MDR, multidrug
The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Human placenta; BCRP; Diethylstilbestrol; Endocrine disruptors; Xenobiotic transporters; Estrogen receptorsABC transporter, ATP-binding cassette transporter; ABCG2, ATP-binding cassette sub-family G member 2; BCRP, breast cancer resistance protein; ATP, a
Alterations in the intestine of Patagonian silverside (Odontesthes hatcheri) exposed to microcystin-LR: Changes in the glycosylation pattern of the intestinal wall and inhibition of multidrug resistance proteins efflux activity
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP-binding cassette; Abcb1, p-glycoprotein; Abcc, multidrug resistance-associated proteins; Bcrp, breast cancer resistance protein; BSA, bovine seroalbumine; calcein-AM, calcein acetoxymethyl ester; CDNB, 1-chloro-2,4-dinitrobenzene; ConA-FITC, fluo
Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ALDH1A1, Aldehyde dehydrogenase 1A1; P-gp, P-glycoprotein; BCRP, breast cancer resistance protein; ATRA, all-trans retinoic acid; DEAB, diethylaminobenzoaldehyde; PAC, paclitaxel; TOP, topotecan; CIS, cisplatin; DOX, doxorubicin; MDR, multiple drug resist
Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; 5′UTR, 5′ untranslated region; ABC, ATP-binding cassette; AP-1, activator protein-1; ATF-2, activating transcription factor-2; BCRP, breast cancer resistance protein; BDL, bile duct ligation; BSEP, bile salt export pump; CAR, constitutive androstane recep
Role and modulation of drug transporters in HIV-1 therapy
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC transporter, ATP-binding cassette membrane transporter; AhR, Aryl hydrocarbon receptor; AIDS, Acquired immunodeficiency syndrome; ARV, Antiretroviral drug; BBB, Blood–brain barrier; BCRP, Breast cancer resistance protein; BTB, Blood–testicular barrier
Lapatinib enhances the cytotoxic effects of doxorubicin in MCF-7 tumorspheres by inhibiting the drug efflux function of ABC transporters
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Lapa, lapatinib; Dox, doxorubicin; ABC, ATP-binding cassette; MRP-1, multidrug resistance-associated protein-1; MDR-1, multidrug resistance protein-1; BCRP, breast cancer resistance protein; HER2, human epidermal growth factor receptor 2; ER, estrogen rec
Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Bcrp, breast cancer resistance protein; Mrp2, multidrug-associated resistance protein 2; DMPS, 2,3 dimercapto-1-propane succinate; Hg2 +, inorganic mercury; OSOM, outer stripe of the outer medulla; Cys, cysteine; SD, Sprague–Dawley; bcrp−/−, Bcrp knockout
Sulfonation of raloxifene in HEK293 cells overexpressing SULT1A3: Involvement of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in excretion of sulfate metabolites
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Raloxifene; Sulfonation; Sulfate conjugate; MRP; BCRP; Efflux transportABC, ATP-binding cassette transporter; BCRP, breast cancer resistance protein; DMEM, Dulbecco's modified Eagle's medium; MRP, multidrug resistance-associated proteins; FBS, fetal bovin
Selection of resistant acute myeloid leukemia SKM-1 and MOLM-13 cells by vincristine-, mitoxantrone- and lenalidomide-induced upregulation of P-glycoprotein activity and downregulation of CD33 cell surface exposure
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; AML, acute myeloid leukemia; BCRP, breast cancer resistance protein; CSA, cyclosporine A; DOX, doxorubicin; GAPDH, glyceraldehyde phosphate dehydrogenase; HSP90, heat shock protein 90; KCA, ketoconazole; Len, lenalidomide; LC50, median of lethal concentra
Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC-transporter; Reserpine; Cluster analysis; Collateral sensitivity; Molecular docking; PharmacogenomicsABC, ATP-binding cassette; BCRP, Breast cancer resistance protein; EGFR, Epidermal growth factor receptor; MAPK, Mitogen-activated protein kinase; MDR
In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; α-SMA, anti-smooth actin; AD, Alzheimer’s disease; Aβ peptide, amyloid β peptide; BBB, blood–brain barrier; BCECs, brain capillary endothelial cells; BCRP, breast cancer resistance protein; CAA, cerebral amyloid angiopathy; CNS, central nervous system; CS
Regional expression of the BCRP/ABCG2 transporter in term human placentas
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP-binding cassette; BCRP, breast cancer resistance protein; cDNA, complementary DNA; Ct, threshold cycle; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PBS, phosphate-buffered saline; PRL, prolactin; RPL13a, ribosomal protein L13a; 18S, 18S ribo
The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP-binding cassette; BCRP, Breast Cancer Resistance Protein; BP, benzo[a]pyrene; BPDE, (+)-anti-BP-7,8-diol-9,10-epoxide; CYP, cytochrome P450 monooxygenase; DJS, Dubin–Johnson Syndrome; hprt, hypoxanthine phosphoribosyltransferase; MRP, Multidrug R
Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; CAR, constitutive androstane receptor; cAMP, cytosolic cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; COX-2, cyclooxygenase 2; BCA, bicinchoninic acid; BCRP, breast cancer resistance protein; MDR, multi-drug resistance; MRP4, multid
Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Pgp, P-glycoprotein; MRPs, multidrug-resistance related proteins; BCRP, breast cancer resistance protein; PEG, polyethylene glycol; DPPG, 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-glycerol; DOTAP, 1,2-dioleoyloxy-3-trimethylammoniumpropanchloride; DPPC, 1,
The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Bcl-2, B cell lymphoma-2; BCRP, breast cancer resistance protein; CML, chronic myeloid leukaemia; DTT, Dithiothreitol; FAC, fluorescence associated cell sorter; FBS, foetal bovine serum; Mcl-1, Myeloid cell leukaemia 1; MDR, multidrug resistance; MRP1, mu
Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; TRPV1, transient receptor potential cation channel; BCRP, breast cancer resistance protein; MRP2, multidrug resistance-associated protein 2; P-gp, P-glycoprotein; RR, ruthenium red; Na-Flu, Na-fluoresceinCapsaicin; Intestinal permeability; Regional differ
Noni increased the systemic exposure of methotrexate in rats through inhibition on multi-drug resistance protein 2 (MRP 2) and breast cancer resistance protein (BCRP)
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; MTX, methotrexate; MRPs, multi-drug resistance proteins; BCRP, breast cancer resistance protein; NSAIDs, non-steroidal anti-inflammatory drugs; HPLC, high-performance liquid chromatography; Cmax, the peak blood concentration; AUC0-t, the areas under the c
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; AHR, aryl hydrocarbon receptor; ANOVA, analysis of variance; BCRP, breast cancer resistance protein; CKD, chronic kidney disease; Ct, cycle threshold; E1S, estrone sulphate; EDX, energy-dispersive X-ray; EM, electron microscopy; eYFP, enhanced yellow fluo
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; MDR, MultiDrug Resistance; ABC, ATP Binding Cassette; P-gp, P-glycoprotein; BCRP, Breast Cancer Resistance Protein; MRP1, MultiDrug Resistance-associated Protein1; Papp, apparent permeability; Calcein-AM, Acetoxymethyl esters of calcein; MDCK, Madin-Darby
Cellular and molecular mechanisms activating the cell death processes by chalcones: Critical structural effects
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ATG, autophagy related genes; Bak, Bcl-2 homologous antagonist killer; Bax, Bcl-2-associated X protein; BCRP, breast cancer resistance protein; Bim, Bcl-2 interacting mediator of cell death; BSA, bovine serum albumine; CAT, catalase; CCD, charge-coupled d
Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; BCRP, breast cancer resistance protein; MRP2, multidrug resistance-associated protein 2; Pgp, P-glycoproteinDrug transporters; Immunoquantification; BCRP; MRP2; P-glycoprotein
Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP-binding cassette; AdhCAR, hCAR-expressing adenovirus; BCRP, breast cancer resistance protein; CAR, constitutive androstane receptor; ChIP, chromatin immunoprecipitation; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldeyde O-(3,4-di
Renal efflux transporter expression in pregnant mice with Type I diabetes
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Abc, ATP-binding cassette; Abca, ATP-binding cassette transporter; AhR, aryl hydrocarbon receptor; Bcrp, breast cancer resistance protein; CAR, constitutive androstane receptor; Cyp, cytochrome P450; HNF1α, hepatocyte nuclear factor 1α; Ho-1, heme oxygena
Oxazaphosphorine bioactivation and detoxification: the role of xenobiotic receptors
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ALDH, aldehyde dehydrogenase; AKR, aldo-keto reductase; AhR, aryl hydrocarbon receptor; BCRP, breast cancer resistance protein; CAA, chloroacetaldehyde; CAR, constitutive androstane receptor; CPA, cyclophosphamide; CYP, cytochrome P450; CMF, cyclophospham
pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; BCRP, breast cancer resistance protein; DAPI, 4′,6-diamidino-2-phenylindole; DDIW, distilled deionized water; DLS, dynamic light scattering; Dox, doxorubicin; Dox-NPs, doxorubicin loaded nanoparticles; EDC, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide h
Preclinical experimental models of drug metabolism and disposition in drug discovery and development
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ADME, absorption, distribution, metabolism and excretion; AO, aldehyde oxidases; AUC, area under the plasma concentration–time course curve; BCRP, breast cancer resistance protein; BDC, bile-duct cannulation; BSEP, bile salt export pump; CYP, cytochrome P
Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP-Binding Cassette; BCRP, breast cancer resistance protein; DMSO, dimethylsulfoxide; DOX, doxorubicin; FTC, Fumitremorgin C; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MDR, multidrug resistance; MRP, multidrug resistance-associate protein; MT
The transfer of 6-mercaptopurine in the dually perfused human placenta
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; 6-MP, 6-mercaptopurine; AZA, azathioprine; BCRP, breast cancer resistance protein; CNT, concentrative nucleoside transporter; TPMT, thiopurine methyltransferase; MRP5, multidrug resistance protein 5; F:M, fetal to maternal; hCG, human chorionic gonadotrop
Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; AhR, aryl hydrocarbon receptor; B[a]P, benzo[a]pyrene; BCRP, breast cancer resistance protein; BP3G, B[a]P-3-glucuronide; BP3S, B[a]P-3-sulfate; CYP, cytochrome P450; DMSO, dimethylsulfoxide; EGCG, (−)-epigallocatechin-3-gallate; EROD, ethoxyresorufin-O-d
Effect of short term and chronic administration of Sutherlandia frutescens on pharmacokinetics of nevirapine in rats
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; CYP, cytochrome P450; MDR1, multi-drug resistance transporter; MRP, multi-drug resistance associated protein; P-gp, P glycoprotein; BCRP, breast cancer resistance protein; sutherlandia, Sutherlandia frutescens; AUC, area under the plasma concentration–tim
Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; BCRP, breast cancer resistance protein; MRP, multidrug resistance protein; OAT, organic anion transporterBioavailability; Food–drug interaction; Isoflavones; Organic anion transporters; Quercetin
2′,5′-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; AP-1, activator protein-1; ARE, antioxidant-response element; BCRP, breast cancer resistance protein; BSO, l-buthionine sulfoximine; 2′,5′-DHC, 2′,5′-dihydroxychalcone; ERK, extracellular-signal-regulated kinase; GCLC, glutamate–cysteine ligase catalytic
Amyotrophic lateral sclerosis: A neurovascular disease
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ALS, amyotrophic lateral sclerosis; AQP4, aquaporin 4; BBB, blood–brain barrier; BCRP, breast cancer resistance protein; BCSFB, blood–cerebrospinal fluid barrier; BSCB, blood–spinal cord barrier; cAMP, cyclic adenosine monophosphate; CNS, central nervous
Transcriptional suppression of breast cancer resistance protein (BCRP) by wild-type p53 through the NF-κB pathway in MCF-7 cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; MDR, multidrug resistance; ABC, ATP-binding cassette; BCRP, Breast cancer resistance protein; MRP, multidrug resistance-associated protein; P-gp, P-glycoprotein; NF-κB, nuclear factor kappa-B; RNAi, RNA interference; wt-p53, wild-type p53; PBS, phosphate
Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Bsep, bile salt export pump; BEI, biliary efflux index; Bcrp, breast cancer resistance protein; ES, estrone-3-sulfate; HBSS, Hank’s balanced salt solution; Clbile,intClbile,int, intrinsic biliary clearance; Mrp2, multidrug resistance associated protein 2;
Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; ABC, ATP-binding cassette; BCRP, breast cancer resistance protein; FACS, fluorescence-activated cell sorter; MDCK, Madin–Darby canine kidney; MDR1, multi-drug resistance 1; MRP, multi-drug resistance protein; MTD, maximum tolerable dose; P-gp, P-glycoprot
A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; AhR, aryl hydrocarbon receptor; AhRE, AhR response element; BCRP, breast cancer resistance protein; ChIP, chromatin immunoprecipitation; CLO, clofibrate; DDI, drug–drug interactions; ER, estrogen receptor; HIF-1, hypoxia-inducible factor-1; 3MC, 3-methylc
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; miRNA, microRNA; MRP-1, multidrug resistance-associated protein 1; MDR, multidrug resistance; MDR-1, multidrug resistance 1; BCRP, breast cancer resistance protein; siRNA, small interfering RNA; RT-PCR, reverse transcription polymerase chain reactionmicro
Glutaric aciduria type I and methylmalonic aciduria: Simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood–brain barrier and the choroid plexus
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; BBB, blood–brain barrier; BCB, blood–cerebrospinal fluid barrier; BCRP, breast cancer resistance protein; bp, base pairs; C0, initial concentration; 14C-GA, 14C-glutaric acid; CNS, central nervous system; CoA, coenzyme A; CPM, counts per minute; CSF, cere
Therapeutic implications of renal anionic drug transporters
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; Renal clearance; Drug transporters; Drug interactions; Transporter polymorphism; Nephrotoxicity; Renal failureABC, ATP-binding cassette; BCRP, breast cancer resistance protein; CMPF, 3-carboxy-4-methyl-5-propyl-2-furanpropionate; CsA, cyclosporine A; DHEA
Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; AP, apical; BCRP, breast cancer resistance protein; BL, basolateral; FCS, foetal calf serum; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; MTs, metallothioneins; MRP2, multidrug resistance protein 2; MTF-1, metal-specific transcription factor-1; OTA, o
Riboflavin concentration within ABCG2-rich extracellular vesicles is a novel marker for multidrug resistance in malignant cells
Keywords: Bcrp، پروتئین مقاوم در برابر سرطان پستان; MDR, multidrug resistance; BCRP, breast cancer resistance protein; FTC, fumitremorgin C; PBS, Phosphate-buffered salineCancer; Anticancer drugs; Multidrug resistance; ABC transporters; Overexpression; Extracellular vesicles; Riboflavin