
Natural phenylalanine hydroxylase variants that confer a mild phenotype affect the enzyme's conformational stability and oligomerization equilibrium
Keywords: BH4, (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin; CD, circular dichroism; Δ13-PAH, PAH missing residues 1–13; DSC, differential scanning calorimetry; Ek, enterokinase; HPA, hyperphenylalaninemia; IPTG, isopropylthio-β-d-galactoside; L-Phe, phenylalanine; L