Keywords: BHR، پاسخگویی برونی مزمن; aOR, adjusted odds ratio; aHR, adjusted hazard ratio; BHR, bronchial hyperresponsiveness; BMI, body mass index; CI, confidence interval; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; GWA, genome-wide association; PR, prev
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Keywords: BHR، پاسخگویی برونی مزمن; Allergic rhinitis; Asthma; Chronic rhinosinusitis; Endoscopic sinus surgery; ImmunotherapyAERD, Aspirin-exacerbated respiratory disease; AR, Allergic rhinitis; BHR, Bronchial hyperresponsiveness; CRS, Chronic rhinosinusitis; ECRS, Eosinophilic chronic rhi
Keywords: BHR، پاسخگویی برونی مزمن; ATS/ERS, American Thoracic Society/European Respiratory Society; BHR, bronchial hyperresponsiveness; FeNO, fractional exhaled nitric oxide; FEV1, forced expiratory volume in one second; FEV1%VC, forced expiratory volume in one second expressed as a percen
Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice
Keywords: BHR، پاسخگویی برونی مزمن; Bronchial asthma; Bronchial hyperresponsiveness; Eosinophil; Eosinophil-deficient mice; Th9 cellsAb, antibody; BALF, bronchoalveolar lavage fluid; BHR, bronchial hyperresponsiveness; H&E, hematoxylin and eosin; i.v., intravenous; MCh, methacholine; OVA, o
Interaction between corticosteroids and muscarinic antagonists in human airways
Keywords: BHR، پاسخگویی برونی مزمن; Airway smooth muscle; Asthma; ICS; LAMA; Drug interactionANOVA, analysis of variance; ASM, airway smooth muscle; BHR, bronchial hyperresponsiveness; BI, Bliss Independence; cAMP, cyclic adenosine monophosphate; COPD, chronic obstructive pulmonary disease;
Exhaled nitric oxide in relation to asthma control: A real-life survey
Keywords: BHR، پاسخگویی برونی مزمن; ACT, asthma control test; BHR, bronchial hyperresponsiveness; FeNO, fraction of exhaled nitric oxide; FEF25–75, forced expiratory flow at 25–75% of vital capacity; FEV1, forced expiratory volume at 1st second; FVC, forced vital capacity; ICS, inhaled cort
Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice
Keywords: BHR، پاسخگویی برونی مزمن; Serotonin 4 receptors; Cigarette smoke; Murine model; COPD5-HT, 5-hydroxytryptamine; AUC, area under the curve; BHR, bronchial hyperresponsiveness; COPD, chronic obstructive pulmonary disease; CS, cigarette smoke
Drug development for severe asthma: What are the metrics?
Keywords: BHR، پاسخگویی برونی مزمن; ACT, Asthma Control Test; AHR, Airway hyperresponsiveness; AMP, Adenosine monophosphate; AQLQ, Asthma Quality of Life Questionnaire; BHR, Bronchial hyperresponsiveness; COPD, Chronic obstructive pulmonary disease; FEV1, Forced expiratory volume in one sec
Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma
Keywords: BHR، پاسخگویی برونی مزمن; BHR, bronchial hyperresponsiveness; CD, Crohn's disease; FBAT, family based association test; FEV1, forced expiratory volume in 1 second; FP, fluorescence polarization; IFN, interferon; IgE, immunoglobulin E; IL, interleukin; indel, insertion–deletion pol
Diagnosis and management of early asthma in preschool-aged children
Keywords: BHR، پاسخگویی برونی مزمن; Asthma; wheezing; preschool; inhaled corticosteroids; leukotriene receptor antagonists; intermittent treatment; wheezing phenotypesAPI, Asthma Predictive Index; BHR, Bronchial hyperresponsiveness; EPR3, Expert Panel Report 3; ERS, European Respiratory Soc
Airway remodeling in asthma: New mechanisms and potential for pharmacological intervention
Keywords: BHR، پاسخگویی برونی مزمن; ADAM, A disintegrin and metalloprotease; ASM, airway smooth muscle; BALF, Bronchoalveolar lavage fluid; BHR, bronchial hyperresponsiveness; [Ca2+]i, concentration of free Ca2+ in the cytosol; CaMK-IV, calcium/calmodulin-dependent protein kinase IV; CCL, C
Bronchial hyperresponsiveness to histamine correlates with airway remodelling in adults with asthma
Keywords: BHR، پاسخگویی برونی مزمن; Bronchial asthma; Bronchial hyperresponsiveness; Acetylcholine; Histamine; Airway remodelling; Eosinophilic inflammationACh, acetylcholine; ASM, airway smooth muscle; BHR, bronchial hyperresponsiveness; FEV1, forced expiratory volume in 1 s; FP, fluticaso
Using genetics to predict the natural history of asthma?
Keywords: BHR، پاسخگویی برونی مزمن; Asthma; genetic; prediction; natural historyADAM-33, A disintegrin and metalloproteinase domain; AUC, Area under the receiver operating characteristic curve; BHR, Bronchial hyperresponsiveness; CAMP, Childhood Asthma Management Program; COPD, Chronic obst
Genetics of allergic disease
Keywords: BHR، پاسخگویی برونی مزمن; Heritability; genetics; genetic testing; pharmacogenetics; epigeneticsADAM33, A disintegrin and metalloprotease 33 gene; ADRB2, β2-Adrenoceptor gene; ARG, Arginase gene; BHR, Bronchial hyperresponsiveness; CNV, Copy number variant; CRHR1, Corticotropin-re
Application of a Shortened Inhaled Adenosine-5′-Monophosphate Challenge in Young Children Using the Forced Oscillation Technique
Keywords: BHR، پاسخگویی برونی مزمن; AMP, adenosine-5′-monophosphate; BHR, bronchial hyperresponsiveness; CI, confidence interval; FOT, forced oscillation technique; PC, provocation concentration; Rrs, respiratory system resistance; Rrs8, respiratory system resistance at 8 Hz; Spo2, pulse ox
Urban Residence Is Associated With Bronchial Hyperresponsiveness in Italian General Population Samples
Keywords: BHR، پاسخگویی برونی مزمن; bronchial responsiveness; epidemiology; general population; methacholine; risk factors; urbanANOVA, analysis of variance; BHR, bronchial hyperresponsiveness; BR, bronchial responsiveness; CI, confidence interval; CNR, National Research Council; MCT, metha
Does measuring BHR add to guideline derived clinical measures in determining treatment for patients with persistent asthma?
Keywords: BHR، پاسخگویی برونی مزمن; AMP, adenosine monophosphate; BAL, bronchoalveolar lavage; BDP, beclomethasone dipropionate; BHR, bronchial hyperresponsiveness; BUD, budesonide; eNO, exhaled nitric oxide; FP, fluticasone propionate; FEV1, forced expiratory volume in 1 s; FPBHR, fluticas
Clinical assessment of asthma progression in children and adults
Keywords: BHR، پاسخگویی برونی مزمن; Asthma progression; natural history of asthma; lung function decline; remission; relapse; birth cohort studies; early interventionAPI, Asthma Predictive Index; BDP, Beclomethasone dipropionate; BHR, Bronchial hyperresponsiveness; CAMP, Childhood Asthma Ma
Safety of Sputum Induction With Hypertonic Saline Solution in Exercise-Induced Bronchoconstriction
Keywords: BHR، پاسخگویی برونی مزمن; asthma; bronchial hyperresponsiveness; exercise; exercise-induced bronchoconstriction; safety; sputum inductionAUC, area under the curve; AUC12PEFR, area under the curve for peak expiratory flow rate/time over 12 min; BHR, bronchial hyperresponsiveness; C
Integrin β3 genotype influences asthma and allergy phenotypes in the first 6 years of life
Keywords: BHR، پاسخگویی برونی مزمن; Asthma; allergy; noncoding variation; integrin; viral respiratory illnessADAM33, A disintegrin and matrix metalloprotease; BHR, Bronchial hyperresponsiveness; COAST, Childhood Onset of ASThma; GEI, Gene-environment interaction; ITGB3, Integrin β3; LD, Lin
The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
Keywords: BHR، پاسخگویی برونی مزمن; Inhaled corticosteroids; predicting response; therapy; characteristics; biomarkersACQ, Asthma Control Questionnaire; ACRN, Asthma Clinical Research Network; BHR, Bronchial hyperresponsiveness; FeNO, Fraction of exhaled nitric oxide; FVC, Forced vital capa
Increased expression of ADAM33 and ADAM8 with disease progression in asthma
Keywords: BHR، پاسخگویی برونی مزمن; ADAM8; ADAM33; asthma severity; bronchial biopsies; immunohistochemistry; mRNAADAM, A disintegrin and metalloproteinase; ASMC, Airway smooth muscle cells; BALF, Bronchoalveolar lavage fluid; BHR, Bronchial hyperresponsiveness; FVC, Forced vital capacity;
Downregulation of a disintegrin and metalloproteinase 33 by IFN-γ in human airway smooth muscle cells
Keywords: BHR، پاسخگویی برونی مزمن; Asthma; airway remodeling; airway smooth muscle; a disintegrin and metalloproteinase 33; IFN-γ; extracellular signal-regulated kinase pathwayADAM, A disintegrin and metalloproteinase; ASM, Airway smooth muscle; BHR, Bronchial hyperresponsiveness; COL1A1,
Severe asthma in adults: What are the important questions?
Keywords: BHR، پاسخگویی برونی مزمن; Epidemiology; pathophysiology; management; research perspectives; severe asthmaATS, American Thoracic Society; BHR, Bronchial hyperresponsiveness; EGFR, Epidermal growth factor receptor; FENO, Fraction of exhaled nitric oxide; ICS, Inhaled corticosteroid;
Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci
Keywords: BHR، پاسخگویی برونی مزمن; Asthma; linkage; founder populationADAM33, A disintegrin and metalloproteinase domain 33; ADAMTS12, A disintegrin and metalloproteinase domain with thrombospondin type 1 motif 12; BHR, Bronchial hyperresponsiveness; EP, Prostaglandin E; HWE, Hardy-Weinber
The role of the mast cell in the pathophysiology of asthma
Keywords: BHR، پاسخگویی برونی مزمن; Mast cells; asthma; airway smooth muscle; bronchial mucous glands; chemokines; TNF-αASM, Airway smooth muscle; BHR, Bronchial hyperresponsiveness; EB, Eosinophilic bronchitis; HLMC, Human lung mast cell; LT, Leukotriene; PAR, Protease-activated receptor;